Sleep Deprivation, Stimulant Medications, and Cognition

Nancy J. Wesensten, PhD, is a supervisory psychologist in the Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, USA.

Foreword: sustaining cognitive performance: a modern imperative David Dinges; Part I. Basic Mechanisms: Cognitive Performance and Sleep: 1. The true nature of sleep loss-Induced 'neurocognitive performance deficits' – a critical appraisal Thomas J. Balkin; 2. Using fMRI to study cognitive function and its modulation in sleep deprived persons – a selective overview Michael W. L. Chee and Su Mei Lee; 3. The neurochemistry of cognitive impairment following sleep loss Robert E. Strecker and James T. McKenna; 4. The genetic basis of individual vulnerability to sleep loss Phillip J. Quartana and Tracy L. Rupp; Part II. Stimulant Reversal of Cognitive Deficits: 5. Modafinil reversal of cognitive deficits during sleep loss Nancy J. Wesensten; 6. Utility of caffeine: evidence from the laboratory Michael H. Bonnet and Donna L. Arand; 7. Caffeine: mechanism of action, genetics and behavioural studies conducted in task simulators and the field Christina E. Carvey, Lauren A. Thompson, Caroline R. Mahoney and Harris R. Lieberman; 8. Stimulants in models of shift work and shift work disorder Jonathan R. L. Schwartz and Aaron M. Henley; 9. The potential for abuse of stimulants in chronically sleep-restricted populations Emma Childs and Harriet de Wit; 10. Cognition enhancers versus stimulants Megan St Peters and Martin Sarter; 11. Novel pathways for stimulant development: the histaminergic system John J. Renger; 12. Novel pathways for stimulant development: the hypocretin/orexin system Ravi K. Pasumarthi and Thomas S. Kilduff; Part III. Alternatives for Sustaining Cognitive Performance During Sleep Loss: 13. Light exposure for improving cognition during sleep loss and circadian misalignment Kenneth P. Wright, Jr, Tina M. Burke and Mark R. Smith; 14. Nutritional countermeasures for cognitive performance decrements following sleep deprivation Caroline R. Mahoney and Harris R. Lieberman; 15. The role of alertness monitoring in sustaining cognition during sleep loss Melissa M. Mallis and Francine O. James; 16. Sustaining neurobehavioral performance on less sleep: is SWS enhancement the key? Janine M. Hall-Porter and James K. Walsh; Part IV. Summary and Conclusions: 17. Use of stimulants in operational settings: issues and considerations Nicholas Davenport, Cheryl Lowry and Brian Pinkston; 18. Fatigue management: the art of the state Tracy L. Rupp, Nancy J. Wesensten and Thomas J. Balkin.