Store-operated Ca2+ entry (SOCE) pathways

Prof. Klaus Groschner studied Pharmacy at the School of Pharmacy, University of Graz, Austria. He completed his PhD studies at the Department of Pharmacodynamics in Graz and received part of his postdoctoral education at the University of Miami, Florida, USA, studying electrophysiology and cell biology. In 1990 he became an Assistant Professor at the Department of Pharmacology and Toxicology and received his Habilitation in Pharmacology and Toxicology along with promotion to Associate Professor in 1993. Until 2011 he was head of a research unit for Physiology and Pharmacology of Membrane Transport at the Institute of Pharmaceutical Sciences at the University of Graz. Since 2012 he is Full Professor and Chairman at the Institute of Biophysics at the Medical University of Graz. Prof. Wolfgang F. Graier studied Pharmacy at the University of Graz, Austria and received his PhD in Pharmacology at the Department of Pharmacology and Toxicology, University of Graz. In 1993 he was a postdoctoral research fellow, analyzing physiology and membrane biophysics at the Dalton Cardiovascular Research Center, University of Missouri, Columbia, USA. In 1994 he became an Assistant Professor at the Department of Medical Biochemistry, University of Graz and Professor in Biochemical Pharmacology at the Medical Faculty in 1995 (Habilitation), and in Physiology in 2001. Since 2006 he is head of the Research Unit for Molecular and Cellular Physiology at the Medical University of Graz. Since 2009 he is Full Professor for Molecular Biology and Chairman of the Institute of Molecular Biology and Biochemistry at the Medical University of Graz.

Preface (C. Romanin, W. F. Graier, K. Groschner).- SECTION 1: SOCE - Fundamental mechanistic concepts.- Introduction (J. W. Putney).- 1.1 The STIM-Orai pathway.- Structural insights into Ca²⁺ sensing by stromal interaction molecules (P. B. Stathopulos, M. Ikura).- 1.2 The STIM-Orai pathway. Orai, the pore-forming subunit of the CRAC channel (P. G. Hogan).- 1.3 The STIM-Orai pathway. The interactions between STIM and Orai (R. Schindl, M. Fahrner, M. Muik, I. Derler, C. Romanin).- 1.4 STIM-TRP pathways. The STIM1/Orai/TRPC channels multiple Ca²⁺ influx complexes (J. H. Hong, M. S. Kim, K. P. Lee, J. P. Yuan, S. Muallem).- 1.5 STIM-TRP pathways. Function and regulation of TRPC1: Contribution to Ca²⁺ entry activated by store depletion (I. S. Ambudkar, K. T. Cheng, H. L. Ong, X. Liu).- 1.6 Microdomain organization and the role of second messengers. Microdomain organization of SOCE signaling (C. Moreno, L. Vaca).- 1.7 Microdomain organization and the role of second messengers. Store-operated Ca²⁺ entry: Endogenous messengers and mediators (V. M. Bolotina).- SECTION 2: SOCE - Crosstalk between organelle and cellular compartments.- Introduction: Ca²⁺ signaling and gene regulation: An introduction (A. B. Parekh).- 2.1 New aspects of the contribut