Multiple Sclerosis – Diagnosis and Therapy

Edited by Howard L. Weiner, MD, Harvard Medical School, Brigham and Women's Hospital & Partners MS Center, Boston, MA, USA James M. Stankiewicz, MD, Harvard Medical School, Brigham and Women s Hospital & Partners MS Center, Boston, MA, USA

List of Contributors, vii Preface, ix Part I Pathology and Diagnosis, 1 1 Disease Pathogenesis, 3 Roopali Gandhi and Howard L. Weiner 2 Biomarkers, 26 Manuel Comabella and Samia J. Khoury 3 Epidemiology and Genetics, 56 Philip L. De Jager 4 Diagnosis, 77 James M. Stankiewicz, Varun Chaubal, and Guy J. Buckle 5 Pediatric Multiple Sclerosis and Acute Disseminated Encephalomyelitis, 101 Tanuja Chitnis 6 Magnetic Resonance Imaging in Multiple Sclerosis, 136 Mohit Neema, Antonia Ceccarelli, Jonathan S. Jackson, and Rohit Bakshi 7 Predicting Clinical Course, 163 Brian Healy and Maria Liguori Part II Management, 181 8 Medication Treatment in Multiple Sclerosis, 183 James M. Stankiewicz and Samia J. Khoury 9 Symptom Management, 213 Lynn Stazzone and Brandon Brown 10 Cognitive Dysfunction in Multiple Sclerosis, 239 Bonnie I. Glanz and Maria K. Houtchens 11 Depression and Other Psychosocial Issues in Multiple Sclerosis, 263 David J. Rintell 12 Future Therapeutic Approaches, 283 Howard L. Weiner and Laura Edwards Index, 301