Redox Regulation of Cell Signaling and Its Clinical Application

Junji Yodoi

Thioredoxin/adult t-cell leukaemia-derived factor (ADF) and redox regulation; dysfunction of redox system by reactive oxygen and nitrogen species; redox regulation of glucocorticoid hormone action - cross-talk between endocrine stress response and cellular antioxidant system; oxidative stress by tumor-derived macrophages induces abnormal structure of t-cell receptor complex; structural basis of thioredoxin-mediated redox regulation; regulation of yAP-1 nuclear localization in response to oxidative stress; a novel antioxidant enzyme, thioredoxin peroxidase and mammalian peroxiredoxins; protective action of adult T cell leukaemia derived factor (ADF)/thioredoxin (TRX) against oxidative damage in the kidney of mice treated with a renal carcinogen, ferric nitrilotriacetate - induction and nuclear translocation of ADF/TRX; cellular response to lipid peroxidation products; primary involvement of oxidative damage and redox imbalance in Alzheimer and other neurodegenerative diseases; roles of Syk protein tyrosine kinase in stress-induced signalling in B cells; redox regulation of the DNA binding activity in transcription factor PEBP2 - the roles of two conserved cysteine residues; reactive oxygen enhanced EGF receptor phosphorylation; redox-oriented chemical events in signal transduction in cells; mammalian peroxiredoxin MSP23 as an oxidative stress-inducible protein; implication of oxidative stress induced in long term uremic complication; thioredoxin - a regulatory protein with potential application in medicine and technology; the elevated serum level of thioredoxin in patients with chronic and/or malignant liver diseases; AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1; oxygen radicals, redox regulation of the NF-kB signalling and disease control by antioxidants; redox regulation of protein function by thioredoxin and glutaredoxin systems; therapeutic potential of alpha-lipoic acid - molecular aspects.