Prostaglandins and Leukotrienes in Gastrointestinal Diseases

Biology and Pharmacology of Prostaglandins and Leukotrienes.- Biosynthesis and Metabolism of Prostaglandins and Thromboxanes. Quantitative Determination in Biological Material.- Discussion.- Involvement of the Eicosanoids, Thromboxane A2 and Leukotriene C4 in Gastric Mucosal Damage.- Discussion.- Microvascular Injury and the Role of Leukotrienes and Prostaglandins in Acute Mucosal Damage and Protection.- Discussion.- Inhibition of Prostaglandin Synthesis and Proliferation of the Gastric Mucosa.- Discussion.- Role of Prostaglandins in Intestinal Fluid Secretion.- Discussion.- Novel Leukotriene D4 Receptor Antagonists and 5-Lipoxygenase Inhibitors: Implications in Human Disease.- Discussion.- Protective Effects on the Gastrointestinal Mucosa. New Aspects of the Last two Years.- "Aggressive" and "Protective" Factors in the Pathogenesis of Peptic Ulcer Disease.- Discussion.- Heartburn and Mucosal Barrier Weakness.- Discussion.- The Functional Role of Prostanoids in the Gastroduodenal Mucosa.- Role of Leukotrienes in Gastric Mucosal Damage and Protection.- Discussion.- Effect of Prostaglandins on the Motility of the Digestive Tract.- Discussion.- Gastroduodenal Bicarbonate Secretion in Mucosal Protection.- Discussion.- Prostaglandins and Cellular Restitution - Physiological and Pathological Implications.- Discussion.- Prostanoid Inhibition of Acid Secretion - Cellular Mechanisms in Canine Fundic Mucosa.- Discussion.- The Protective Effects of Prostaglandins on the Gastric Microvasculature.- Non-Steroidal Anti-Inflammatory Drugs and Peptic Ulcer.- Discussion.- Mechanism of Injury to Gastric Mucosa by Non-Steroidal Anti-Inflammatory Drugs and the Protective Role of Prostaglandins.- Discussion.- Can Nonantisecretory Doses of Prostaglandins Prevent Mucosal Damage inNon-Steroidal Anti-Inflammatory Drugs?.- Clinical Aspects of the Protective Effects of Prostaglandins on Non-Steroidal Anti-Inflammatory Drug-Associated Mucosal Injury.- Discussion.- Prostaglandins and Leukotrienes in Gastrointestinal Diseases - Present Clinical Role.- Gastrointestinal Microbleeding and Ulcerogenic Drugs: Prevention by Co-Administration of Prostaglandins.- Discussion.- Exogenous Prostaglandins and Their Analogues in Gastric Ulcer Therapy.- Exogenous Prostaglandins and Their Analogues in Duodenal Ulcer Therapy.- Discussion.- Clinical Safety of Antiulcer Prostaglandins: An Overview.- Discussion.- Ulcer Healing Drugs and Endogenous Prostaglandins: Carbenoxolone, Antacids, Sucralfate, Bismuth, and H2-Receptor Antagonists.- Discussion.- Smoking and Ulcer Healing - Role for Prostaglandins?.- Discussion.- Ulcer Healing by Prostaglandins - Due to Decreased Acidity or Enhanced Mucosal Defense?.- Discussion.- Diarrheagenic Syndromes Sensitive to Prostaglandin Synthetase Inhibitors.- Discussion.- Colitis and Non-Steroidal Anti-Inflammatory Drugs.- Discussion.- Therapeutic Role for Prostaglandins in Ulcerative Colitis?.- Discussion.- Inflammatory Bowel Disease: Treatment Modalities and Mucosal Prostaglandin/Leukotriene Formation.- Discussion.- Prostaglandins: Their Potential Therapeutic Value in the Upper Gastrointestinal Tract.- The Natural History of Ulcer Disease and its Impact upon Therapeutic Options and Assessment of Drug Safety.- Benefits and Risks of Long-Term Medical Therapy with Histamine H2-Receptor Antagonists in Ulcer Disease - A Physician's View.- Benefits and Risks of Long-Term Medical Therapy with Histamine H2-Receptor Antagonists in Ulcer Disease: A Surgeon's View.- The Surgical Approach to Ulcer Disease and its Complications - Hasthere been a Change in the Last Decade?.- The Efficacy of Prostaglandins in the Prevention of Stress Lesions in the Critically I11 Patient.- Discussion Following this Section.