Pharmaceutics

Design of dosage forms. PART ONE SCIENTIFIC PRINICIPLES OF FORMULATION SCIENCE Solutions and their properties. Rheology and flow. Surface and interfacial phenomena. Solubility and dissolution rate. Disperse systems. Kinetics and product stability. PART TWO PARTICLE SCIENCE AND POWDER TECHNOLOGY Solid-state properties of powders. Particle size analysis. Particle size reduction. Particle size separation. Mixing. Powder flow. PART THREE BIOPHARMACEUTICS PRINCIPLES OF DRUG DELIVERY Introduction to Biopharmaceutics. Factors influencing bioavailability. Assessment of bioavailability. Dosage Regimens. Sustained and extended release. PART FOUR DOSAGE FORM DESIGN AND MANUFACTURE Preformulation. Solutions, Suspensions and Emulsions. Filtration. Powders and granules. Granulation. Drying. Tablets and compaction. Tablet coating. Capsules and encapsulation. Pulmonary drug delivery. Nasal delivery. Rectal and vaginal delivery. Parenteral products. Transdermal drug delivery. Delivery of proteins/biotech products. Packs and packaging. Materials of fabrication and corrosion. Heat transfer and the properties of steam. PART FIVE PHARMACEUTICAL MICROBIOLOGY AND STERILIZATION Fundamentals of microbiology. The action of physical and chemical agents on micro-organisms. Microbiological contamination and preservation. Principles of sterilization. Sterilization practice. Design and operation of clean rooms.