Diagnostic Atlas of Renal Pathology

Dr. Agnes Fogo, M.D., F.A.S.N. serves as Member of Scientific Advisory Board of Angion Biomedica Corp. Dr. Fogo is the John L. Shapiro Chair of Pathology, Professor of Pathology, Medicine and Pediatrics and Director, Division of Renal Pathology and Electron Microscopy at Vanderbilt University Medical Center. An expert in the area of glomerulosclerosis, Dr. Fogo has published over 280 research articles and reviews and has authored two textbooks of renal pathology. She has served as Pathology Editor for the American Journal of Kidney Disease, Associate Editor for American Journal of Pathology and The Journal of the American Society of Nephrology. She is currently Section Editor for Nephrology Dialysis and Transplantation and Associate Editor for Laboratory Investigation. Michael Kashgarian, MD is professor emeritus of and senior research scientist in pathology. He received his medical degree from Yale School of Medicine in 1958, completed his residency in pathology at the Yale-New Haven Medical Center in 1963, and completed a fellowship in laboratory medicine at Yale-New Haven Hospital in 1964. While on the Yale faculty he established a diagnostic renal pathology and electron microscopy laboratory that bears his name. He was also a pioneer in understanding the process of organ rejection. Although Kashgarian has retired, he continues to be active in the diagnosis of renal and cardiac biopsies.

Chapter 1 Glomerular Diseases

NORMAL GROWTH AND MATURATION

PRIMARY GLOMERULAR DISEASES

Glomerular Diseases that Cause Nephrotic Syndrome: Non-Immune Complex

Introduction

Minimal Change Disease

Focal Segmental Glomerulosclerosis

Collapsing Glomerulopathy

Tip Lesion Variant of FSGS

Cellular Variant of FSGS

Perihilar Variant of FSGS

Congenital Nephrotic Syndrome of Finnish Type

Diffuse Mesangial Sclerosis

Glomerular Diseases that Cause Nephrotic/Nephritic Syndrome: Complement-Related

C1q Nephropathy

Dense Deposit Disease

C3 Glomerulopathies

Glomerular Diseases that Cause Nephrotic Syndrome: Immune Complex

Membranous Nephropathy

Membranoproliferative Glomerulonephritis Type 1

Fibrillary Glomerulonephritis

Immunotactoid Glomerulopathy

Glomerular Diseasesthat Cause Hematuria or Nephritic Syndrome: Immune Complex

Acute Post-infectious Glomerulonephritis

IgA Nephropathy

SECONDARY GLOMERULAR DISEASES

Diseases Associated with Nephrotic Syndrome

Monoclonal Immunoglobulin Deposition Disease

Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposition

HIV-associated Nephropathy

Sickle Cell Nephropathy

Fabry's Disease

Lipoprotein Glomerulopathy

Lecithin-Cholesterol Acyltransferase Deficiency

Hereditary FSGS

Diseases Associated with Nephritic Syndrome or RPGN: Immune-Mediated

Lupus Nephritis, Mesangial and Proliferative Types

Henoch-Sch�nlein Purpura

Mixed Connective Tissue Disease

Mixed Cryoglobulinemic Glomerulonephritis

Anti-GBM-Antibody Mediated Glomerulonephritis

Diseases Associated with Nephritic Syndrome or RPGN: Pauci-Immune- or Non-Immune-Mediated

Introduction

Granulomatosis with Polyangiitis (Wegener's)/Microscopic Polyangiitis

Polyarteritis Nodosa

Churg-Strauss Syndrome

Diseases of the Basement Membrane

Alport Syndrome

Thin Basement Membrane Lesions

Nail-Patella Syndrome

Glomerular Involvement with Bacterial Infections

Subacute Bacterial Endocarditis Glomerulonephritis

Shunt Nephritis

Chapter 2 Vascular Diseases

Diabetic Nephropathy

Thrombotic Microangiopathy/Thrombotic Thrombocytopenic Purpura

Scleroderma (Progressive Systemic Sclerosis)

Anti-phospholipid Antibody Disease

Preeclampsia and Eclampsia

Fibromuscular Dysplasia

Arterionephrosclerosis

Accelerated/Malignant Hypertension

Atheroemboli

Chapter 3 Tubulointerstitial Diseases

Introduction

Acute Pyelonephritis

Chronic Pyelonephritis and Reflux Nephropathy

Xanthogranulomatous Pyelonephritis

Malakoplakia

Acute Tubulointerstitial Nephritis-Drug-Related

Acute Tubulointerstitial Nephritis--Viral Infection

Anti-Tubular Basement Membrane Antibody Nephritis

IgG4-Related Tubulointerstitial Nephritis

Sarcoidosis

Acute Kidney Injury/Acute Tubular Necrosis

Heavy Metal Nephropathy (Lead and Cadmium Nephropathy)

Analgesic Nephropathy and Papillary Necrosis

Light Chain Cast Nephropathy and Tubulopathy

Tubular Crystallopathies

Indinavir Nephropathy

Lithium Nephropathy

Aristolochic Acid Nephropathy

Chapter 4 Chronic Kidney Disease

Introduction

Age-Related Sclerosis

Glomerular vs. Tubulointerstitial vs. Vascular Disease

Segmental Glomerulosclerosis-Primary vs. Secondary

Chapter 5 Renal Transplantation

Introduction��

Antibody-Mediated Rejection��

Chronic Active Antibody-Mediated Rejection and Transplant Glomerulopathy

Acute T-Cell-Mediated Rejection

Chronic Allograft Failure (Chronic Allograft Nephropathy)

Cyclosporin/FK506 Nephrotoxicity��

Post-Transplant Lymphoproliferative Disease��

Viral Infections��

Chapter 6 Cystic Diseases of the Kidney

Introduction��

Autosomal dominant polycystic kidney disease��

Autosomal recessive polycystic kidney disease��

Medullary cystic disease��

Medullary sponge kidney��

Acquired cystic disease��

Cystic renal dysplasia��

Chapter 7 Renal Neoplasia

Introduction��

Renal Cell Carcinomas��

Other Renal Epithelial Tumors��

Wilms' Tumor��

Transitional Cell Carcinoma of the Renal Pelvis��