Heparin-Induced Thrombocytopenia, Fifth Edition

Theodore E. Warkentin, MD, FACP, FRCPC is a professor in the Department of Pathology and Molecular Medicine, and the Department of Medicine, at McMaster University, Canada. Prof. Dr. Andreas Greinacher is professor and head of the Department of Transfusion Medicine and the Hemostasis Service at the Medical School and Hospital of the Ernst-Moritz-Arndt-University Greifswald, CEO and chief of staff of the University Hospital Greifswald, and visiting professor at McMaster University Hamilton, Canada.

History of Heparin-Induced Thrombocytopenia. Clinical Picture of Heparin-Induced Thrombocytopenia. Differential Diagnosis of Heparin-Induced Thrombocytopenia and Scoring Systems. Frequency of Heparin-Induced Thrombocytopenia. Nonimmune Heparin-Platelet Interactions: Implications for the Pathogenesis of Heparin-Induced Thrombocytopenia. Role of Heparin-Dependent Antigens in Immune Heparin-Induced Thrombocytopenia. Role of Sulfated Polysaccharides and other Polyanions in the Pathogenesis of Heparin-Induced Thrombocytopenia. Platelet and Leukocyte Fcγ Receptors in Heparin-Induced Thrombocytopenia. Cellular and Molecular Immunopathogenesis of Heparin-Induced Thrombocytopenia. Murine Models of Heparin-Induced Thrombocytopenia. Laboratory Testing for Heparin-Induced Thrombocytopenia. Treatment of Heparin-Induced Thrombocytopenia: An Overview. Argatroban Therapy in Heparin-Induced Thrombocytopenia. Recombinant Hirudin for the Treatment of Heparin-Induced Thrombocytopenia. Bivalirudin for the treatment of Heparin-Induced Thrombocytopenia. Danaparoid for the Treatment of Heparin-Induced Thrombocytopenia. Fondaparinux and Other Emerging Anticoagulants to Treat Heparin-Induced Thrombocytopenia. Hemodialysis in HIT. Management of Intraoperative Anticoagulation in Patients with Heparin-Induced Thrombocytopenia Undergoing Cardiovascular Surgery. Heparin-Coated Intravascular Devices and Heparin-Induced Thrombocytopenia. Heparin-Induced Thrombocytopenia in Children. A Clinician’s Perspective on Heparin-Induced Thrombocytopenia: Paradoxes, Myths, and Continuing Challenges.