Problem-based Approach to Gastroenterology and Hepatology

J.N. Plevris MD, PhD, FRCP(E) Consultant Gastroenterologist & Senior Lecturer, Centre for Liver & Digestive Disorders, The Royal Infirmary of Edinburgh and Hepatology Laboratory, University of Edinburgh Medical School, Edinburgh, UK Subrata Ghosh MD (Edin) FRCP, FRCP (E) Gastrointestinal section, Imperial College School of Medicine, London, UK Colin W. Howden MD, PhD Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, USA

Preface vii

Contributors viii

Part One Gastroenterology

1 Dysphagia 3
Nirmala Gonsalves, Ikuo Hirano, and John N. Plevris

2 The Problem of Heartburn, and Atypical Chest Pain 17
Ronnie Fass and Tiberiu Hershcovici

3 The Clinical Approach to Dyspepsia 39
Mary Farid and Brennan Spiegel

4 Acute, Recurrent, and Chronic Abdominal Pain 44
Brian E. Lacy and Chad C. Spangler

5 Hematemesis, Melena, and Occult Bleeding/Anemia 64
Grigorios I. Leontiadis and Virender K. Sharma

6 Acute Diarrhea and Vomiting 72
John P. Flaherty and Michael P. Angarone

7 Chronic Diarrhea and Malabsorption 84
Paul Beck, Remo Panaccione, and Subrata Ghosh

8 Rectal Bleeding 96
Matthew Shale, Lotte Dinesen, and Subrata Ghosh

9 Multisystem Disorders and Gastrointestinal Disease 106
Lynne A. Meekison and John N. Plevris

Part Two Hepatology and Pancreatobiliary

10 Clinical Approach to Pancreatobiliary Disease 117
Erica J. Revie, Lisa J. Massie, Anne-Marie Lennon, and O. James Garden

11 The Problem of Right Upper Quadrant Pain 132
Malcolm B. Barnes and Simon Glance

12 Abnormal Liver Function Tests: Diagnostic Approach 144
Timothy T. Gordon-Walker and John P. Iredale

13 The Acute Liver Failure Patient 162
Neil C. Henderson and Kenneth J. Simpson

14 The Chronic Liver Disease Patient 174
Joanna K. Dowman and Phil N. Newsome

15 Portal Hypertension: A Management Problem 189
Norma C. McAvoy and Peter C. Hayes

16 Infections in the Liver 202
Veerendra Sandur and George Therapondos

17 The Liver Transplant Recipient 212
Prakash Ramachandran and Andrew J. Bathgate

18 Incidental Radiological Findings in the Asymptomatic Patient 226
Tiffany J. Campbell and Dilip Patel

Index 241