Paraneoplastic Syndromes

Dr. Darnell studied neurology as Chief Resident with Dr. Fred Plum at The New York Hospital, Cornell, and then, beginning in 1990 and continuing through the present time, with Dr. Jerome Posner at Memorial Sloan-Kettering Cancer Center. Dr. Darnell is currently the Heilbrunn Cancer Professor and Senior Physician at The Rockefeller University and an Investigator with the Howard Hughes Medical Institute, and is an Affiliate Attending Neurologist at Memorial Sloan-Kettering Cancer Center. Dr. Posner did a Neurology residency at the University of Washington under Dr. Fred Plum. C. Cotzias of Neuro-Oncology at Memorial Sloan-Kettering cancer Center and was recently in only clinical research professor ship from the American Cancer Society.

Contents ; SECTION 1 OVERVIEW ; 1. HISTORY ; DEFINITIONS ; CLASSIFICATION ; HISTORY ; Pathogenesis ; EPIDEMIOLOGY ; IMPORTANCE ; 2. CLINICAL FINDINGS, TREATMENT AND PROGNOSIS ; INTRODUCTION ; CLINICAL APPROACH ; The Patient without Known Cancer The Patient with Known Cancer ; CLUES TO DIAGNOSIS ; Clinical Findings Laboratory Investigation ; PATHOLOGY ; TREATMENT ; Plasma Exchange (Plasmapheresis) Intravenous Immunoglobulin ; Rituximab Cyclophosphamide Corticosteroids Human Chorionic Gonadotropin Recommendations ; PROGNOSIS ; 3. PATHOGENESIS ; INTRODUCTION ; HISTORICAL VIEWS ; Toxic Substances Competition for Essential Substrate Bullet Opportunistic Infection Immune Mediated ; CURRENT CONCEPTS OF PATHOGENESIS ; Unresolved Questions Conclusions ; ANIMAL MODELS ; SECTION 2 CLINICAL SYNDROMES ; 4. BRAIN (CEREBRUM) ; INTRODUCTION ; CEREBRAL CORTEX ; WHITE MATTER DEMYELINATION ; BLOOD VESSELS (VASCULITIS) ; HIPPOCAMPUS/LYMBIC ENCEPHALITIS ; TASTE