Therapeutic Advances in Thrombosis

David Moliterno, M.D, co-director of the Gill Heart Institute, professor of Internal Medicine and division chief of Cardiovascular Medicine at the University of Lexington, Kentucky. He is also inaugurated as the American College of Cardiology Governor of the Kentucky chapter for the years 2007-2010. He has 189 articles published as listed on PubMed and is the author of the following books: Therapeutic Strategies in Thrombosis 1E; 900 Questions: An Interventional Cardiology Board Review. Raffaele De Caterina, MD, Institute of Cardiology, "G. d'Annunzio" University, Chieti, Italy. He has 261 articles published as listed on PubMed and is the author of the following books: Therapeutic Strategies in Thrombosis 1E; Endothelial Dysfunctions and Vascular Disease. Steen Dalby Kristensen, Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark. He has 91 articles published as listed on PubMed and is the author of the following books: Therapeutic Strategies in Thrombosis 1E.

Contributors, vii Foreword, x Preface, xi 1 Arterial thrombosis: a brief overview, 1 Lina Badimon and Valentin Fuster 2 Aspirin, 12 Carlo Patrono 3 Platelet ADP P2Y12 inhibitors: thienopyridines, 26 Joseph D. Foley III and David J. Moliterno 4 Platelet ADP P2Y12 inhibitors: nonthienopyridines, 47 Joseph D. Foley III and David J. Moliterno 5 Cilostazol and dipyridamole: more than weak inhibition of platelets, 62 Wolfgang G. Eisert 6 Interrelationship of thrombin and platelets: the protease activated receptor-1, 71 Matthew E. Wiisanen and David J. Moliterno 7 Glycoprotein IIb/IIIa inhibitors, 87 Marco Valgimigli and Elisa Cangiano 8 Unfractionated heparin and low molecular weight heparin in ischemic heart disease, 111 Zafar Iqbal, Omar Hasan, and Marc Cohen 9 Pentasaccharide derivatives, 128 Antonio Gutierrez, Pierluigi Tricoci, and John H.P. Alexander 10 Intravenous direct thrombin inhibitors, 150 Femi Philip and A. Michael Lincoff 11 Vitamin K antagonists, 166 Freek W.A. Verheugt 12 Oral direct thrombin inhibitors and oral factor Xa inhibitors, 180 Steen Husted and Lars Wallentin 13 Thrombolytic therapy and concomitant antithrombotic therapies, 189 Peter R. Sinnaeve and Frans J. Van de Werf 14 Antithrombotic therapy in ST-segment elevation myocardial infarction, 205 Kurt Huber, Raffaele De Caterina, and Steen Dalby Kristensen 15 Antithrombotic therapy in non ST-segment elevation acute coronary syndromes, 213 Georgios J. Vlachojannis, Vijayalakshmi Kunadian, Joseph M. Sweeny, and Roxana Mehran 16 Antithrombotic strategies in patients undergoing elective percutaneous coronary intervention, 236 Sunil V. Rao and E. Magnus Ohman 17 Antithrombotic management in patients with prosthetic valves, 246 Eric G. Butchart and Raffaele De Caterina 18 Stroke: thrombolysis and antithrombotic therapy, 272 L. Creed Pettigrew and Michael R. Dobbs 19 Atrial fibrillation: current and forthcoming antithrombotic therapies, 285 Raffaele De Caterina and Giulia Renda 20 Venous thromboembolism: pathophysiology, diagnosis, and prophylaxis, 306 Marco P. Donadini, Walter Ageno, and Alexander G. Turpie 21 Antithrombotic therapy in venous thrombosis and pulmonary embolism, 317 Marcello Di Nisio and Harry R. Buller 22 Prevention and treatment of venous and arterial thrombosis in patients with specific conditions: diabetes, hypercoagulable states, pregnancy, and renal insufficiency, 327 Meyer Michel Samama, Jacqueline Conard, and Grigoris Gerotziafas 23 Genetics of the response to antithrombotic drugs and the need for monitoring, 357 Jean-Philippe Collet, Gilles Montalescot, and Jean-Sebastien Hulot Index, 378