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Neurotoxicology

Jean Harry G, Hugh A. Tilson (Herausgeber)

Buch | Hardcover
386 Seiten
1999 | 2nd New edition
Taylor & Francis Ltd (Verlag)
978-1-56032-720-2 (ISBN)
145,90 inkl. MwSt
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Provides a basis for a better understanding about the sites and mechanisms of neurotoxicity, as well as the adverse effects of chemicals on the nervous system. Also reviews recent advances in neurotoxicological research.
This second edition of Neurotoxicology is valuable for scientists in government and industry who are responsible for public health and for the safe and efficient use of chemicals. This integrated approach to neurotoxicology will aid in the understanding of the sites and mechanisms of neurotoxicity, stimulate the formulation of testable hypotheses about how chemicals affect the nervous system, and help improve the risk assessment process.
This edition focuses primarily on the neurobiological basis underlying neurotoxic sites and modes of action. The contents include:
*molecular biological and in vitro approaches
*potential cellular and molecular sites involving neuron-glia interactions
*axonal transport
*ion channels
*metabolic influences on neurotoxicity
*role of free radical formation in neurotoxicity
*interaction between chemicals and trophic factors
*endocrine disruptors
*apoptosis in neurotoxicity
*in vivo brain imaging
*advances in measuring cognitive function
*advances in developing quantitative models for neurotoxicology/risk assessment

Preface; 1. Molecular Biological Approaches in Neurotoxicology Arell D. Toews and Poerre Morell 2. In Vitro Neurotoxicology Marion Ehrich and Bellina Veronesi 3. Neuron-Glial Interactions as Potential Targets of Neurotoxicant Effect Richard M. LoPachin and Michael Aschner 4. The Role of Axonal Transport in Toxicant-Induced Peripheral Neuropathy Jeffry F. Goodrum 5. The Role of Ion Channels in Neurotoxicity Timothy J. Shafer 6. Metabolic Influences on Neurotoxicity in the Central Nervous System Martin A. Philbert, Dennis C. Morse, Kenneth R. Reuhl, and Herbert E. Lowndes 7. Reactive Oxygen Species and Antioxidant Homeostasis in Neurotoxicology Prasada Rao S. Kodavanti 8. Applications of the Neurotrophic Hypothesis to Developmental Neurotoxicology Stan Barone, Jr. 9. Endocrine Disruption: Estrogen, Androgen, and the Nervous System Diane B. Miller 10. Neuroimmunotoxicology G. Jean Harry and Alessandra Bruccoleri 11. Apoptosis and Neurotoxicity Usamah S. Kayyali and Rudy J. Richardson 12. Effect of Neurotoxins Revealed Through In Vivo Brain Imaging Edith V. Sullivan, Margaret Rosenbloom, and Adolf Pfefferbaum 13. Learning and Behavior Change as Neurotoxic Endpoints M. Christopher Newland and Phyllis A. Reile 14. Assessing Neurotoxicity in Children Joseph L. Jacobson and Sandra W. Jacobson 15. Quantitative Risk Assessment in Neurotoxicology: Past, Present and Future R. C. MacPhail and J. R. Glowa Jr., U.S. Environmental Protection Agency, Alessandra Bruccoleri, National Institute of Environmental Health Sciences, Marion Ehrich, Virginia-Maryland Regional College of Veterinary Medicine, John R. Glowa, Louisiana State University Medical Center at Shreveport, Jeffry F. Goodrum, University of North Carolina, G. Jean Harry, National Institute for Environmental Health Science, Joseph L. Jacobson, Wayne State University, Sandra W. Jacobson, Wayne State University, Usamah S. Kayyali, Harvard Medical School, Prasada Rao S. Kodavanti, U.S. Environmental Protection Agency, Richard M. LoPachin, Albert Einstein College of Medicine, Herbert E. Lowndes, Rutgers University, Robert C. MacPhail, U.S. Environmental Protection Agency, Diane B. Miller, National Institute for Occupational Safety and Health, Pierre Morell, University of North Carolina, Dennis C. Morse, Rutgers University, M. Christopher Newland, Auburn University, Adolf Pfefferbaum, SRI International, Martin A. Philbert, University of Michigan School of Public Health, Phyllis A, Reile, Auburn University, Kenneth R. Reuhl, Rutgers University, Rudy J. Richardson, Univeristy of Michigan, Margaret Rosenbloom, Stanford University School of Medicine, Timothy J. Shafer, U.S. Environmental Protection Agency, Edith V. Sullivan, Stanford University School of Medicine, Arrel D. Toews, University of North Carolina, Bellina Veronesi, U.S. Environmental Protection Agency

Erscheint lt. Verlag 22.7.1999
Reihe/Serie Target Organ Toxicology Series
Verlagsort London
Sprache englisch
Maße 152 x 229 mm
Gewicht 689 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Neurologie
Studium 2. Studienabschnitt (Klinik) Pharmakologie / Toxikologie
Naturwissenschaften Biologie Biochemie
Naturwissenschaften Biologie Humanbiologie
Naturwissenschaften Biologie Zoologie
ISBN-10 1-56032-720-0 / 1560327200
ISBN-13 978-1-56032-720-2 / 9781560327202
Zustand Neuware
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