The Structure of Biological Membranes

Philip L. Yeagle is dean of the Faculty of Arts and Sciences and chief academic research officer at Rutgers University, Newark, New Jersey. He obtained his PhD at Duke University in 1974. As a postdoctoral fellow at the University of Virginia, he started his studies of membrane structure and dynamics, supported by an NIH postdoctoral fellowship. There he was one of the first investigators to discover and exploit the opportunities for 31P NMR studies of model and biological membranes. He began his faculty career in the School of Medicine, University at Buffalo, supported by an NIH RCDA, during which time he was able to define the molecular basis of an essential role of cholesterol in mammalian cell membranes. In 1985, he was a visiting scientist at the CSIRO, New South Wales, Australia, and in 1988 he developed the first in a series of FASEB Summer Research Conferences on membrane structure. In 1993, and again in 2003, he was a visiting professor in the Department of Biochemistry, University of Oxford. He moved in 1997 to the Department of Molecular and Cell Biology at the University of Connecticut as head of department and pursued studies of membrane protein structure. He was elected member of the Council of the Biophysical Society and chair of the Membrane Structure and Assembly subgroup that he helped form. He was executive editor of Biochemica et Biophysica Acta Biomembranes for a decade and a member of the editorial board of the Journal of Biological Chemistry. He has published over 150 papers and reviews and is the author or editor of seven books.

Introduction to Lipid Bilayers. Membrane Proteins. Introduction to Lipid–Protein Interactions in Biological Membranes. The Mesomorphic Phase Behavior of Lipid Bilayers. IR Spectroscopy of Lipid Chains: Theoretical Background and Applications to Phase Transitions, Membranes, Cells, and Tissues. The Roles of Cholesterol in the Biology of Cells. Functional Consequences of the Lateral Organization of Biological Membranes. Mechanisms by Which Pathogens Hijack and Utilize Membrane Domains to Mediate Cytotoxicity. Lipid-Assisted Membrane Protein Folding and Topogenesis. Membrane Protein Biogenesis and Assembly at the Endoplasmic Reticulum Membrane. Thermal Denaturation of Membrane Proteins. Mass Action Kinetic Analysis of Multidrug Resistance Transporters Expressed in Confluent Cell Monolayers. How to Understand Lipid–Protein Interactions in Biological Membranes. Biogenesis of Lipids and Proteins within Mitochondrial Membranes. Index.