Models for Assessing Drug Absorption and Metabolism

1 General Principles in the Characterization and Use of Model Systems for Biopharmaceutical Studies.- 2 Methods for Evaluating Intestinal Permeability and Metabolism in Vitro.- 3 Cultured Intestinal Epithelial Cell Models.- 4 Intestinal Rings and Isolated Intestinal Mucosal Cells.- 5 Models of Drug Absorption in Situ and in Conscious Animals.- 6 Model Systems for Intestinal Lymphatic Transport Studies.- 7 Buccal Tissues and Cell Culture.- 8 Isolated Hepatocytes.- 9 Cultured Rat Hepatocytes.- 10 Isolated Perfused Liver.- 11 Isolated Renal Brush Border and Basolateral Membrane Vesicles and Cultured Renal Cells.- 12 Use of An Isolated Perfused Kidney to Assess Renal Clearance of Drugs: Information Obtained in Steady-State and Non-Steady-State Experimental Systems.- 13 Brain Microvessel Endothelial Cell Culture Systems.- 14 Methods to Study Drug Transport in Isolated Choroid Plexus Tissue and Cultured Cells.- 15 Brain Perfusion Systems for Studies of Drug Uptake and Metabolism in the Central Nervous System.- 16 In Vitro Nasal Models.- 17 Models for Investigation of Peptide and Protein Transport across Cultured Mammalian Respiratory Epithelial Barriers.- 18 Drug Transport across Xenopus Alveolar Epithelium in Vitro.- 19 In Situ and in Vivo Methods for Pulmonary Delivery.- 20 In Vitro Viable Skin Model.- 21 Isolated Perfused Porcine Skin Flap Systems.- 22 Vaginal Epithelial Models.- 23 Ocular Epithelial Models.