Essential Haematology

Victor Hoffbrand is Emeritus Professor of Haematology at University College London and Honorary Consultant Haematologist at the Royal Free Hospital, London Paul Moss is Professor of Haematology at the University of Birmingham, UK

Preface to the Sixth Edition vii Preface to the First Edition ix How to get the best out of your textbook x 1 Haemopoiesis 1 2 Erythropoiesis and general aspects of anaemia 15 3 Hypochromic anaemias 33 4 Iron overload 50 5 Megaloblastic anaemias and other macrocytic anaemias 58 6 Haemolytic anaemias 73 7 Genetic disorders of haemoglobin 88 8 The white cells 1: granulocytes, monocytes and their benign disorders 108 9 The white cells 2: lymphocytes and their benign disorders 126 10 The spleen 142 11 The aetiology and genetics of haematological malignancies 150 12 Management of haematological malignancy 166 13 Acute myeloid leukaemia 178 14 Chronic myeloid leukaemia 191 15 The non-leukaemic myeloproliferative neoplasms 200 16 Myelodysplasia 214 17 Acute lymphoblastic leukaemia 223 18 The chronic lymphoid leukaemias 234 19 Hodgkin lymphoma 245 20 Non-Hodgkin lymphoma 253 21 Multiple myeloma and related disorders 272 22 Aplastic anaemia and bone marrow failure 288 23 Stem cell transplantation 297 24 Platelets, blood coagulation and haemostasis 314 25 Bleeding disorders caused by vascular and platelet abnormalities 330 26 Coagulation disorders 345 27 Thrombosis and antithrombotic therapy 362 28 Haematological changes in systemic disease 381 29 Blood transfusion 397 30 Pregnancy and neonatal haematology 413 Appendices 1 Normal values 424 2 World Health Organization classifi cation of tumours of the haematopoietic and lymphoid tissues 426 Index 431