Mechanisms of Cell Death Induced by Photodynamic Therapy with Hypericin

General Introduction 1.Photodynamic therapy 2.Cell Death Mechanisms 3.Aims and Strategies of the Study Materials and Methods 1.Materials and Antibodies 2.Methods Apoptotic and Anti-Apoptotic signaling pathways induced by PDT with Hypericin 1.PDT with hypericin induces apoptosis and necrosis 2.Role of MAPKs in hypericin-induced apoptosis 3.PDT-induced Bcl-2 phosphorylation is associated with growth arrest in the G2/M phase of the cell cycle BCL-2 overexpression reveals a caspase-dependent mechanism of PDT-induced cytochrome C release 1.Introduction 2.Results 3.Discussion and Conclusions Summary and perspectives Samenvatting References