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Mononuclear Phagocytes in the Central Nervous System
Springer-Verlag Berlin and Heidelberg GmbH & Co. K
978-3-540-08958-2 (ISBN)
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A pre- sentation based on the hypothesis that the cell types of the central nervous system have po- tentially identical kinetics and functional potency has not been published.
A. Formulation of the Problem and Relevant Literature.- I. "Mononuclear Phagocyte System".- Conclusion.- II. Literature Dealing with Mononuclear Phagocytes in the Central Nervous System.- 1. Progressive Microglia.- 2. Perivascular Cells of Intracerebral Vessels.- 3. Free Subarachnoidal Cells.- 4. Epiplexus Cells.- Conclusion.- III. Considerations on the Origin of Mononuclear Phagocytes in the Central Nervous System.- 1. Homoplastic Genesis.- a) Resting and Progressive Microglia.- b) Perivascular Cells of Intracerebral Vessels.- c) Free Subarachnoidal Cells.- d) Epiplexus Cells.- 2. Local Heteroplastic Genesis.- a) Progressive Microglia and Neuroglia.- b) Microglia and Subependymal Glia.- c) Progressive Microglia and Perivascular Cells.- d) Progressive Microglia and Free Subarachnoidal Cells.- e) Progressive Microglia and Epiplexus Cells.- f) Progressive Microglia, Perivascular Cells, and Free Subarachnoidal Cells..- g) Progressive Microglia, Perivascular Cells, and Epiplexus Cells.- h) Progressive Microglia, Free Subarachnoidal Cells, and Epiplexus Cells.- i) Perivascular Cells and Free Subarachnoidal Cells.- j) Free Subarachnoidal Cells and Epiplexus Cells.- k) Epiplexus Cells and Epithelial Cells of the Choroid Plexus.- 3. Hematogenesis.- a) Progressive Microglia and Blood Cells.- b) Progressive Microglia, Perivascular Cells, and Blood Cells.- c) Progressive Microglia, Perivascular Cells, and Free Subarachnoidal Cells, and Blood Cells.- d) Free Subarachnoidal Cells and Blood Cells.- e) Free Subarachnoidal Cells, Epiplexus Cells, and Blood Cells.- f) Epiplexus Cells and Blood Cells.- Conclusion.- B. Author's Investigation.- Materials and Methods Consistently Used.- I. Origin of Mononuclear Phagocytes of the Nervous System.- 1. Local Proliferation.- 2. Hematogenesis.- 3. Monocytic Origin.- a) Investigations of the Hematogenesis of Mononuclear Phagocytes in the Central Nervous System of Rabbits.- b) Investigations of the Monocytic Origin of Mononuclear Phagocytes in the Central Nervous System.- c) Investigations of the Monocytic Origin of Mononuclear Phagocytes in the Nervous System which Avoid Tracer Reutilization.- 4. Lymphocytic Origin.- Conclusion.- II. Mode of Distribution and Possible Lymphatic Efflux of Intracerebrally Injected Corpuscular Particles and Cellular Elements.- 1. Corpuscular Particles.- 2. Cellular Elements.- Conclusion.- III. Functional Activity of Mononuclear Phagocytes of the Central Nervous System.- 1. Phagocytosis Experiments.- a) Phagocytic Reaction of Local Cells Following Intracerebral Application of Labeling Material.- b) Giant Cell Formation.- c) Phagocytic Reaction of Human Cerebrospinal Fluid Cells.- 2. Cytochemical Investigations.- 3. Investigations with Immunologic "Markers".- a) Leptomeningeal Membrane Specimens.- b) Cells of the Subarachnoid, Ventricular, and Perivascular Spaces.- c) Human Cerebrospinal Fluid Cells.- d) Glass-Induced Inflammatory Cells in the Sense of Progressive Microglia.- e) Brain of the Athymic or So-Called Nude Mouse.- f) Application of Anti-Lymphocyte and Anti-Monocyte Sera to Human Brain Tissue.- Conclusion.- C. Discussion and Conclusion.- I. Explanation of the Author's Findings.- 1. Cytogenesis.- a) Undamaged Animals.- b) Animals with a Lesion of the Nervous System.- 2. Distribution and Fate.- a) Intracerebral Distribution.- b) Lymphatic Efflux.- 3. Function.- a) Nonimmunologic Activity.- b) Immunologic Activity.- II. Mononuclear Phagocytes of the Central Nervous System and the "Mononuclear Phagocyte System".- 1. Identity.- 2. Significance.- III. Summary of the Author's Investigations.- References.
Reihe/Serie | Schriftenreihe Neurologie / Neurology Series ; 21 |
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Übersetzer | Margaret M. Clarkson |
Zusatzinfo | biography |
Verlagsort | Berlin |
Sprache | englisch |
Gewicht | 475 g |
Themenwelt | Medizin / Pharmazie ► Allgemeines / Lexika |
ISBN-10 | 3-540-08958-6 / 3540089586 |
ISBN-13 | 978-3-540-08958-2 / 9783540089582 |
Zustand | Neuware |
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