Comprehensive Clinical Hepatology

Dr John (Jack) Lake is (despite being only 43 years of age!) one of the foremost hepatologists practising in the US at this time. He is Professor of Medicine and Surgery, Director of the Gastroenterology Division and Medical Director of the Liver Transplant Program at the University of Minneapolis. He has a prodigious publications record, and is adviser and reviewer for a large number of professional journals. He was invited to join the editorial team by DrO'Grady, who identified him as the kind of young, dynamic individual whose enthusiasm and international reknown will attract top-grade international contributors to the project.

Dr John O'Grady can be seen as Dr Lake's equivalent in the UK. He has recently taken over as Director of one of the World's most prestigious centres for the study of liver diseases - the Institute of Liver Studies at King's College Hospital, London. Like Dr Lake, he has a prodigious record of publications, and contributes extensively to high level texts in hepatology (he is one of the only UK-based contributors to Schiff & Schiff!) and transplantation.

Dr Peter Howdle is a Senior Lecturer in Medicine at the University of Leeds, and Consultant Gastroenterologist at St James's University Hospital in Leeds. He was responsible forsetting up the Liver Transplant unit at St James's in 1990, and worked very closely with Dr O'Grady when he headed the unit (1992 to 1996). The unit carries out over 80 transplants per year. Dr Howdle has been a Visiting Lecturer at Harvard University Medical School, and has recently been appointed Professor of Clinical Education for the University of Leeds. He has been an Editor for Bailliere's International Practice and Research series in Clinical Gastroenterology - and hence has numerous contacts and a great deal of invaluable educational and editorial experience.

O'Grady, Lake and Howdle -Comprehensive Clinical Hepatology

8 Hotsheet

Forewordv Prefacevi Acknowledgementsvi Contributorsix Section 1: Normal Structure and Function Anatomy of the Normal Liver Bernard C Portmann Cellular Biology of the Normal Liver Guangsheng Fan and Clifford J Steer Function of the Normal Liver Richard H Moseley Section 2: Clinical Manifestations of Liver Disease Clinical Evaluation of the Patient with Liver Disease Peter D Howdle Jaundice Steven D Lidofsky Gastrointestinal Hemorrhage and Portal Hypertension John R Lake and Peter D Howdle Ascites and Spontaneous Bacterial Peritonitis Vincente Arroyo, Ramon Bataller and Pere Gines Hepatorenal Syndrome and Other Renal Diseases Kevin Moore Hepatic Encephalopathy Kevin D Mullen Associated Systemic Conditions of Liver Disease Robert S Brown Jr and Steven L Zacks Section 3: Specific Diseases of the Liver Viral Hepatitis A and E John G OGrady Viral Hepatitis B and D Anna Suk-Fong Lok and Henry Lik-Yuen Chan Hepatitis C and G George Webster, Simon Whalley, Eleanor Barnes and Geoffrey Dusheiko HIV and the Liver Johannes Koch and Lawrence S Kim Miscellaneous Infections of the Liver Fredric Regenstein and Shaukat Iftikhar Autoimmune Hepatitis Michael P Manns and Christian P Strassburg Primary Biliary Cirrhosis James Neuberger Primary Sclerosing Cholangitis Russell H Wiesner Alcoholic Liver Disease Nick Sheron Hemochromatosis Martin Lombard Wilsons Disease M Stuart Tanner Metabolic Diseases of the Liver Richard G Quist, Alistair J Baker, Anil Dhanwan and Nathan M Bass Pediatric Liver Disease Deirdre A Kelly Benign Tumors and Cystic Diseases of the Liver John Karani Malignant Tumors of the Liver Philip J Johnson Biliary and Cholestatic Diseases Gregory T Everson Vascular Diseases of the Liver Peter Clive Hayes and Syed Hasnain Ali Shah Pregnancy and the Liver Michael A Heneghan Drug- and Toxin-Induced Liver Disease Suzanne Norris Acute Liver Failure John G OGrady Hepatobiliary Dysfunction in the Critically Ill Julia A Wendon and Andrew Rhodes The Liver in Systemic Disease Rolland C Dickson Non-transplant Surgery and the Liver J Michael Henderson and David Vogt Section 4: Liver Transplantation Indications and Patient Selection Didier Samuel, Jose Figueiro and Henri Bismuth The Transplant Operation Milan Kinkhabwala and Jean Crawford Emond Immunology and Immunosuppression Geoffrey W McCaughan Infective Complications Carlos V Paya and Irene G Sia Technical Complications Peter Neuhaus, Andrea R Mueller and Klaus-Peter Platz Graft Dysfunction Federico G Villamil and Fernanda G Zingale Retransplantation Peter J Friend Index