Creatine Kinase Isoenzymes

1 Introduction.- 1.1 Creatine Kinase in Muscular Metabolism.- 1.2 Creatine Kinase in Clinical Chemistry.- 1.3 Creatine Kinase Isoenzymes.- 1.4 Scope and Summary of this Book.- 2 Creatine Kinase Isoenzymes.- 2.1 The Cytoplasmic Isoenzymes from Human Tissues.- 2.2 The Mitochondrial Isoenzyme from Human Heart Muscle.- 3 Methods for Differentiation and Quantitation of Creatine Kinase Isoenzymes.- 3.1 Methods for Determination of Creatine Kinase Activity.- 3.2 Differentiation of Isoenzymes by Non Immunological Methods..- 3.3 Measurement of Isoenzyme Activity by Immunological Methods..- 3.4 Experimental Comparison of Methods for Differentiation of Isoenzymes.- 3.5 Measurement of Isoenzyme Concentration by Immunoassay..- 4 Tissue Specific and Subcellular Distribution of Creatine Kinase Isoenzymes.- 4.1 Tissue Specific Distribution.- 4.2 Subcellular Distribution.- 4.3 Ontogeny.- 5 Clinical Results: Myocardium.- 5.1 Myocardial Infarction.- 5.2 Infarct Size Estimation from Serial Analyses of CK and Isoenzyme Activity..- 5.3 Perioperative Infarction.- 5.4 Complications, Differential Diagnosis, and Diagnostic/ Therapeutic Procedures Associated with Myocardial Infarction..- 5.5 Heart Failure and Inflammation..- 6 Clinical Results: Skeletal Muscle.- 6.1 Direct Skeletal Muscle Damage..- 6.2 Muscular Dystrophies..- 6.3 Hypothyroidism..- 6.4 Various Muscular Diseases..- 6.5 Collagen Diseases..- 7 Clinical Results: Central Nervous System.- 7.1 Cerebral Diseases..- 7.2 Acute Psychosis..- 8 Clinical Results: Gastrointestinal Tract, Liver, and Pancreas..- 8.1 Gastrointestinal Tract Diseases.- 8.2 Liver Diseases.- 8.3 Pancreatic Diseases.- 9 Clinical Results: Kidney and Urogenital Tract..- 9.1 Renal Diseases.- 9.2 Prostatic Carcinoma.- 10 Clinical Results: Intoxication.- 10.1 Exogenous Intoxication..- 10.2 Alcoholism..- 11 Clinical Results: Perinatal Period..- 11.1 Enzymes in Pregnancy.- 11.2 Myometrium and Placenta.- 11.3 Maternal Serum During Pregnancy, Labor, and After Delivery.- 11.4 Cord Blood.- 11.5 Discussion.- 11.6 Summary.- 12 The Creatine Kinase 242 BB Isoenzyme..- 12.1 Distribution ofCK-BB in Human Tissues.- 12.2 Problems in Evaluation of Published Data.- 12.3 Serum CK-BB Activity.- 12.4 CK-BB in Cerebrospinal Fluid.- 12.5 "Idiopathic" and "Macro" Serum CK-BB.- 12.6 Genetic Variants.- 12.7 Summary.- References.- List of Abbreviations.