Mononitrates

Preface.- Introductory Remarks on the Development of Isosorbide-5-Mononitrate.- Vasodilation with Nitrates.- Nitrates: Mechanism of Vasodilation.- Effect of Different Vasodilators on Epicardial Coronary Arteries.- Effects of Isosorbide-5-Mononitrate on Hemodynamic Parameters and on Regional Myocardial Ischemia in Conscious Dogs.- Isosorbide-5-Mononitrate Increases Cyclic Guanosine Monophosphate Concentration in Rat Aorta in Vitro and in Vivo.- Activation of Counter-Regulatory Mechanisms on Administration of Equipotent Doses of Different Types of Vasodilators to Conscious Dogs.- Differences in the Metabolism of Isosorbide-5-Mononitrate and Isosorbide Dinitrate and Their Consequences for Toxicologic Findings.- Clinical Pharmacology.- Pharmacokinetics of ISDN, Sustained-Release ISDN, and IS-5-MN.- Vascular Pharmacokinetics of Nitrates.- Effect of Glyceryl Trinitrate, Isosorbide-5-Mononitrate, and Propranolol on Apparent Liver Blood Flow.- Kinetics of IS-5-MN and Its Glucuronide in Patients with Renal Failure.- Pharmacokinetics of IS-5-MN after Oral and Intravenous Administration in Patients with Hepatic Failure.- Tolerance to Nitrates.- Nitrate Tolerance: Animal Experiments And Clinical Studies in Heart Failure.- Development and Disappearance of Tolerance to Organic Nitrates in Conscious Dogs.- Tolerance and Rebound Phenomena in Nitrate Therapy.- Tolerance to the Antiischemic Effect of Isosorbide Dinitrate during Continuous but not during Intermittent Oral Therapy.- Clinical Relevance of Nitrate Tolerance.- A Double-Blind Cross-Over Study on the Effectiveness and Possible Development of Tolerance during Long-Term Therapy with Isosorbide-5-Mononitrate or Isosorbide Dinitrate Slow-Release in Coronary Artery Disease.- Nitrate Tolerance in Angina Pectoris.- Comparison of the Hemodynamic Effects of Various Doses of Isosorbide-5-Mononitrate Following Single-Dose and Long-Term Administration in Patients with Coronary Heart Disease.- Slow-Release IS-5-MN for the Treatment of Angina Pectoris: Duration of Effects.- Nitrates in Coronary Insufficiency.- The Mechanism of Nitrates in the Relief of Rest Angina.- Beneficial Effects of Isosorbide-5-Mononitrate on Exercise Performance in Patients with Chronic Stable Angina Pectoris.- Comparison of Changes on Exercise-Induced Ischemia After a Single Oral Dose of IS-5-MN and ISDN.- Double-Blind, Randomized Cross-Over Study on the Coronary Therapeutic Efficacy and Tolerance of IS-5-MN (ISMO 20) in Comparison with IS-5-MN + Metipranolol (ISMO-DISORAT 20/5) and Placebo.- The Efficacy of IS-5-MN in Patients with Ischemic Heart Disease: A Pilot Study.- Efficacy of Isosorbide-5-Mononitrate in the Prevention of Induced Attacks of Vasospastic Angina: Preliminary Results.- Double-Blind Comparison of the Effects of Nifedipine and Isosorbide-5-Mononitrate on the Circulatory Response to Exercise, Exercise Tolerance, and ST-Segment Depression in Patients with Ischemic Heart Disease.- Clinical Importance of the Coronary Steal Phenomenon: Are the Coronary Steal Phenomenon after Dipyridamole and the Antianginal Efficacy of Isosorbide Dinitrate of Nifedipine Related to Coronary Anatomy?.- Effect of Nitroglycerin Patches on Hemodynamic and Exercise Parameters in Patients with Coronary Artery Disease Compared with IS-5-MN and Placebo.- Double-Blind, Cross-Over Study on the Antianginal Efficacy of IS-5-MN and ISDN s.r., a Multicenter Trial.- Hemodynamic Effects of Isosorbide-5-Mononitrate in Patients with Coronary Artery Disease, at Rest and Under Exercise.- The Effects of Isosorbide-5-Mononitrate on Left Ventricular FunctionAssessed by Systolic Time Intervals.- Assessment of Changes in Left Ventricular Performance Induced by Nitrates at Rest Using an ECG-Gated Scintillation Probe Device.- Nitrates in Heart Failure.- Nitrate Therapy of Congestive Heart Failure.- Efficacy of IS-5-MN (ISMO 20) in Patients with Coronary Artery Disease and Impaired Left-Ventricular Function.- Hemodynamic Effects of IS-5-MN in Patients with Congestive Heart Failure.