Voltage–Gated Ion Channels as Drug Targets

David J. Triggle is a Professor for Pharmacy at the State University of New York at Buffalo, USA, where he is investigating drug-receptor interactions and has specialized in ion channel pharmacology. He is the author of several books, has contributed around 350 papers, chapters and reviews, and has presented over 1,000 lectures worldwide. David Rampe is currently head of the Safety Pharmacology Department at Sanofi-Aventis Pharmaceuticals in Bridgewater, NJ, USA. Over the past 17 years he has worked in both the discovery and development areas of the pharmaceutical industry. Wei Zheng is a Group Leader at the NIH Chemical Genomics Center. He was previously a Group Leader at Merck's centralized screening center. Over the past 12 years he has being working in the area of assay development and high throughput screening. Murali Gopalakrishnan is a Project Leader in the Neuroscience Research Division of Abbott Laboratories, Illinois, USA. Over the past 12 years he has been engaged in various drug discovery programs in the areas of central nervous system, urology and pain.

Preface.1. Introduction-On Ion Channels (M. Gopalakrishnan, et al.).2. The Voltage-gated Ion Channel Superfamily (W. Catterall).3. State-dependent Drug Interactions with Ion Channels (S. McDonough & B. Bean).4. Assay Technologies: Techniques Available for Quantifying Drug-Channel Interactions (D. Leishman & G. Waldron).5. Calcium Channels (C. Doering & G. Zmponi).6. Sodium Channels (D. Krafte, et al.).7. Potassium Channels (M. Gopalakrishnan, et al.).8. Genetic and Acquired Channelopathies (K. Bracey & D. Wray).Index.