Molecular Determinants of Radiation Response

Buch | Hardcover
276 Seiten
2011
Springer-Verlag New York Inc.
978-1-4419-8043-4 (ISBN)

Lese- und Medienproben

Molecular Determinants of Radiation Response -
160,49 inkl. MwSt
Molecular Determinants of Radiation Response includes chapters by expert authors who detail the present understanding of key DNA damage response pathways and proteins. The chapters include comprehensive discussions on where and how specific alterations in function of these pathways and proteins result in substantive modifications of cellular response to DNA injury. Given the importance of therapies that induce DNA injury in the management of human disease, this book is timely and relevant for basic and translational researchers, as well as clinicians alike.

Molecular Basis of the DNA Damage Responses.- ATM signaling and DNA Damage.- H2AX in DNA Damage Response.- Dynamic Imaging of DNA Damage Foci.- DNA Damage Signaling Downstream of ATM.- Checkpoint Control and Radiation.- Chromatin Responses to DNA Damage.-DNA Damage Response and Senescence.- C. elegans and DNA Damage.- Modulation of Radiation Responses – Opportunities for Therapeutic Exploitation.- The Stem Cell and Radiation.- Role of the Cell Membrane in Signaling Radiation Injury.- Hypoxia and Modulation of Cellular Radiation Response.- Role of PARP and PARP Inhibition in Cellular Response to Radiation.- Anti-angiogenic Therapies and Radiation Responses.- Gene Therapy and Radiation.- Radiation-mediated Molecular Targeting.- EGFR Signaling and Radiation.- Heat and Heat Shock Proteins Modulation of Radiation Response.- Radiation-induced Immune Modulation.

Reihe/Serie Current Cancer Research
Zusatzinfo XVI, 276 p.
Verlagsort New York, NY
Sprache englisch
Maße 155 x 235 mm
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Studium
Schlagworte Strahlentherapie
ISBN-10 1-4419-8043-1 / 1441980431
ISBN-13 978-1-4419-8043-4 / 9781441980434
Zustand Neuware
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