NF-kB in Health and Disease

Michael Karin (Herausgeber)

Buch | Hardcover
VIII, 268 Seiten
2011 | 2011
Springer Berlin (Verlag)
978-3-642-16016-5 (ISBN)
160,49 inkl. MwSt
Nearly 25 years of research have uncovered many diverse functions for the dimeric transcription factor NF-kappaB. NF-kappaB affects most aspects of cellular physiology-from immunity and inflammation to apoptosis, cell survival, growth, and proliferation.

Nearly 25 years of intensive research have uncovered many diverse functions for the dimeric transcription factor known as NF-kappaB (nuclear factor-kappaB). NF-kappaB affects most aspects of cellular physiology-from immunity and inflammation to apoptosis, cell survival, growth, and proliferation

Preface.- Understanding the Logic of IkappaB:NF-kappaB Regulation in Structural Terms.- IKK regulation and human genetics.- Specialized chromatin patterns in the control of inflammatory gene expression.- Macrophages and NF-kappaB in Cancer.- NF- B/Rel proteins and the humoral immune responses of Drosophila melanogaster.- IKK and NF-kappaB mediated functions in carcinogenesis.- Control of NF-kappaB activity by proteolysis.- NF-kappaB as a target for oncogenic viruses.- NF-kappaB and Innate Immunity.- Inhibition of NF-kappaB signaling as a strategy in disease therapy.- NF- B and mucosal homeostasis.- NF-kappaB In liver cancer - the plot thickens.- Subject index.

Erscheint lt. Verlag 6.5.2011
Reihe/Serie Current Topics in Microbiology and Immunology
Zusatzinfo VIII, 268 p.
Verlagsort Berlin
Sprache englisch
Maße 155 x 235 mm
Gewicht 553 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Medizin / Pharmazie Studium
Schlagworte cell survival • inflammatory gene expression • mucosal homeostasis • NEMO molecule • oncogenic viruses • regulation of NF-kB signalling • tumor-associated macrophages
ISBN-10 3-642-16016-6 / 3642160166
ISBN-13 978-3-642-16016-5 / 9783642160165
Zustand Neuware
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