Phosphoinositide 3-kinase in Health and Disease
Springer Berlin (Verlag)
978-3-642-14815-6 (ISBN)
PI3K - From the bench to the clinic and back.- Oncogenetic mutations of PIK3CA in human cancers.- Structural effects of oncogenic PI3Kalpha mutations.- Comparing the roles of the p110 and p110 isoforms of PI3K in signaling and cancer.- Phophatidylinositol 3-kinase (PI3K): the oncoprotein.- AKT Signaling in Physiology and Disease.- Faithfull modeling of PTEN loss driven diseases in the mouse.- PI3K as a target for therapy in haematological malignancies.- Clinical Development of Phosphatidylinositol-3 Kinase Pathway Inhibitors.- From the bench to the bed side: PI3K pathway inhibitors in clinical development.- New Inhibitors of the PI3K-Akt-mTOR Pathway: Insights into mTOR Signaling From a New Generation of Tor Kinase Domain Inhibitors (TORKinibs).- Small molecule inhibitors of the PI3-kinase family.- Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance.- Subject index Contents of sister volume 1:PI3K Book Introduction.- PDK1: The major transducer of PI 3-kinase actions.- Protein Kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway.- Regulatory subunity of class IA PI3K.- The Regulation of Class IA PI 3-kinases by Inter-Subunit Interactions.- Phosphoinositide signalling pathways in metabolic regulation.- Role of RAS in the regulation of PI 3-kinase.- More than just kinases: the scaffolding function of PI3K.- PI3K signalling in neutrophils.- PI 3-kinase p110 Regulation of Platelet Integrin IIb 3.- PI3Ks in lymphocyte signaling and development.- the neurodevelopmental implication of PI3K signaling.- PI3kinase regulation of skeletal muscle hypertrophy and atrophy.- Taking PI3Kdelta and PI3Kgamma one step ahead - Dual active PI3Kdelta/gamma inhibotrs for the treatment of immune -mediated inflammatory diseases.- Subject index
Erscheint lt. Verlag | 1.10.2010 |
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Reihe/Serie | Current Topics in Microbiology and Immunology |
Zusatzinfo | X, 306 p. 79 illus., 46 illus. in color. |
Verlagsort | Berlin |
Sprache | englisch |
Maße | 155 x 235 mm |
Gewicht | 604 g |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie |
Medizin / Pharmazie ► Studium | |
Schlagworte | haematological malignancies • malignant glioma • Oncogenesis • oncoprotein • PDK1 • PIK3 • TOR kinase domain inhibitor |
ISBN-10 | 3-642-14815-8 / 3642148158 |
ISBN-13 | 978-3-642-14815-6 / 9783642148156 |
Zustand | Neuware |
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