The Physical Basis of Biochemistry

Kevin Hallock, Ph.D., is a researcher and instructor in the Department of Anatomy and Neurobiology at the Boston University School of Medicine in Boston, Masschusetts, where he teaches biostatistics, an graduate course on the science of disasters, and co-teaches biophysical chemistry and modeling courses with Dr. Bergethon. His research interests include the impact of antimicrobial peptide on phospholipid bilayers, solid-state NMR and magnetic resonance imaging characterization of crystalline solids, atherosclerotic plaque formation, magnetic resonance microscopy of arthropods, the impact of chronic Hg exposure on aging, and the role cell membrane biophysics play in the fundamental processes of neurophysics. Peter Bergethon, MD is the Head of the Neuroscience Interdisciplinary Modeling and Simulation Center (NIMS Center), the Laboratory for Intelligence Modeling and Neurophysics and a member of the faculty in both the Departments of Anatomy/Neurobiology and Biochemistry at Boston University School of Medicine. His research spirals around a core question: "What is the physical and systemic basis for creativity and intelligent behavior and how could such behavior be practically constructed or reconstructed?" Dr. Bergethon is also an active member of the American Academy of Neurology from which he received the Founder's Award , the Electrochemical, Biophysical, American Chemical Societies, the Society for Neuroscience and the American Society of Biochemistry and Cellular Biology.

Principles of Biophysical Inquiry.Philosophy and Practice of Biophysical Study.Overview of the Biological System Under Study – Descriptive Models.Physical Thoughts, Biological Systems - The application of modeling principles to understanding biological systems.Probability and Statistics.- Foundations.Physical Principles: Energy - The Prime Observable.Biophysical Forces in Molecular Systems.An Introduction to Quantum Mechanics.Chemical Principles.Measuring the Energy of a System: Energetics and the First Law of Thermodynamics.Entropy and the Second Law of Thermodynamics.Which Way Did That System Go? The Gibbs Free Energy.The Thermodynamics of Phase Equilibria.- Building a Model of Biomolecular Structure.Water: A Unique Structure, A Unique Solvent.Ion-Solvent Interactions.Ion-Ion Interactions.Lipids in Aqueous Solution.Macromolecules in Solution.Molecular Modeling - Mapping Biochemical State Space.The Electrified Interphase.- Function and Action Biological State Space.Transport and Kinetics: Processes Not at Equilibrium.Flow in a Chemical Potential Field: Diffusion.Flow in an Electrical Field: Conduction.Forces Across Membranes.Kinetics - Chemical Kinetics.Bioelectrochemistry – Charge Transfer in Biological Systems.- Methods for the Measuring Structure and Function.Separation and Characterization of Biomolecules Based on Macroscopic Properties.Determining Structure by molecular interactions with photons: Electronic Spectroscopy.Determining Structure by molecular interactions with photons: Scattering Phenomena.Analysis of Structure - Microscopy.- Physical Constants