Handbook of Marine Natural Products

Ernesto Fattorusso; Full Professor of Organic Chemistry at the University of Naples "Federico II" William H. Gerwick; Full Professor of Oceanography and Pharmaceutical Sciences, University of California, San Diego Orazio Taglialatela-Scafati; Associate Professor of Organic Chemistry at the University of Naples "Federico II" All three editors have previously written books: Modern Alkaloids. Structure, Isolation, Synthesis, and Biology. (E. Fattorusso and O. Taglialatela-Scafati eds.). Wiley Ed., October 2007. Flavour and Fragrance Chemistry (V. Lanzotti and O. Taglialatela-Scafati eds.). Kluwer Academic Publisher, November 2000. Oceans and Human Health, Risks and Remedies from the Sea (P.J. Walsh, S.L. Smith, L.E. Fleming, H.M. Solo-Gabriele, W.H. Gerwick) Academic Press (Elsevier) 2008. Ernesto Fattorusso was assistant professor at the University of Naples (1963-75); in 1975 he became full Professor of Organic Chemistry at the Faculty of Science. In 1980 he moved to the Faculty of Pharmacy, where he was elected Dean twice. In 2002 he won the A. Quilico Award (Società Chimica Italiana) and in 2004 the P. Scheuer Award (Akademie of Erfurt). He has published more than 300 research papers. Orazio Taglialatela Scafati got the Ph.D. in "Bioactive Natural Products" in 1997, under the supervision of Prof. Fattorusso. Currently, he is Associate Professor in Organic Chemistry, Faculty of Pharmacy, University of Naples "Federico II". His research interests deal with isolation, structure elucidation and semisynthetic transformations of bioactive secondary metabolites from marine invertebrates and terrestrial plants. He is the author of 45 research papers and the editor of the book "Flavour and Fragrance Chemistry".

Introduction.- Taxonomy and marine natural products research.- Chemistry of microalgae and macroalgae.- Chemistry of marine bacteria and fungi.- Chemistry of marine invertebrates (sponges).- Chemistry of marine invertebrates (tunicates).- The role of databases in marine natural products research.- Strategies for structural assignment of MNP through advanced 2D NMR techniques.- Configuration assignment of marine natural products.- Prediction of NMR data through quantum-mechanical calculations.- Contemporary Strategies in Natural Products Structure Elucidation.- Antipredatory defensive role of natural products from marine invertebrates.- Antipredatory defensive roles of planktonic MNPs.- Anti-fouling activity of MNP.- Chemical interactions among marine competitors, and host-pathogens.- Marine Metabolites and Metal Ion Chelation.- Biosynthetic studies through feeding experiments.- Biosynthetic studies through molecular genetics approaches.- Mechanisms of halogenation of marine secondary metabolites.- Enzyme Inhibitors from Marine Invertebrates.- Marine Natural Products that target Microtubules.- Antiprotozoan Marine Natural Products.- Mechanism-based screening for cancer therapeutics with examples from the discovery of marine natural product-based HIF-1 inhibitors.- Fluorescent proteins from the oceans: Marine macromolecules of utility to medicine and biotechnology.- From biosilica of sponges to fabricated biomedical materials.- Meeting the supply needs of marine natural products.- Legal and ethical issues involving marine biodiscovery and development.- Synthesis of Marine Natural Product Leads.- Seafood toxins: classes, sources and toxicology.- Detection of marine toxins through LC/MS techniques.- Marine protein toxins.- Conclusions: The future of marine natural products chemistry.