Frontiers in Thyroidology

Plenary Lectures.- Thyrotropin-releasing Hormone Action in Thyrotropic Cells: Mechanism of Stimulation of Thyroid-stimulating Hormone Secretion.- Thyroid Hormones and the Developing Brain.- Iodine-sufficient Goiter and Autoimmune Thyroiditis: The Kentucky and Colombian Experience.- Neonatal Hypothyroid Screening: Nationwide Experience in Japan.- Iodine Deficiency, the Thyroid, and the Brain.- Prolactin, TSH, and Thyroid Hormones.- An Overview of the Neuroendocrine Control of TSH and PRL, TSH Biosynthesis, Pituitary Deiodinase, and TSH-producing Tumors.- The Neuroregulation of TSH and Prolactin Secretion.- TSH Biosynthesis.- Role of the Pituitary Iodothyronine 5'deiodinase Activity in the Negative Feedback by Thyroid Hormone upon TSH Release.- TSH-secreting Pituitary Tumors.- Inherited Disorders.- Emerging Concepts in Inherited Disorders of Thyroid Metabolism.- Hereditable Defects in Thyroid Peroxidase Function.- Hereditary Goiter with Thyroglobulin Deficiency.- Thyroid Hormone-binding Plasma Proteins.- Inherited Disorders of Thyroid Hormone Action.- Growth Control of Follicular Cell In Vitro.- Expectations in the Study on Growth Regulation of Thyroid Epithelial Cells In Vitro.- Growth Control of Follicular Cells In Vitro.- Control of Proliferation and of the Expression of Differentiation in Thyroid Cells in Culture.- Post-receptor Events in Growth Control.- Growth Control and Follicular Cell Neoplasia.- Clinical Problems in Thyroid Disease.- Clinical Problems in Thyroid Disease.- Transplacental Antibody-induced Neonatal Syndromes.- Labeled Antibodies in the Localization and Therapy of Thyroid Carcinoma.- Amiodarone and the Thyroid.- Thyrotropin: Structure, Receptor Binding, and Assay Methods.- Isolation and Characterization of the Gene Encoding the ?-subunit of Rat Thyrotropin.- Isolation of a Gene Encoding Human Thyrotropin Beta Subunit.- Autoradiographical Portrayal of Distribution Patterns of TSH Receptors in Human Thyroid Gland Tissues.- Bovine Thyrotropin Binding Sites in Nuclei and Nuclear Matrix of Porcine Thyrocytes.- Flow Cytometric Analysis of TSH Binding to its Receptors.- Ganglioside and Phospholipid Content in Normal and Pathological Human Thyroid.- Characterization of the Optimal Thyrotropin (TSH) Induced Cyclic AMP Accumulation in the Cloned Human Thyroid Cell Line (GEJ).- Clinical Experience with a Sensitive Immunoradiometric Assay for Serum Thyrotropin (TSH): Diagnostic and Therapeutic Implications for Hyperthyroid and Thyroid Cancer Patients.- A Highly Sensitive, Non-isotopic Assay for Human TSH with Extended Clinical Utility.- Measurement of Circulating Thyrotropin Concentrations by an Immunochemiluminometric Assay.- Evaluation of Patients on Thyroxine (T4) Replacement with a Highly Sensitive Commercial TSH Immunoradiometric Assay (TSH-IRMA).- Studies of Calmodulin-like Portion in the TSH Receptor.- Regulation, Secretion, and Action of TSH, and Control of Thyroid Function.- TSH Secretory Regulation: New Evidence that Triiodothyronine (T3) and Thyroxine (T4) Can Inhibit TRH Secretion Both In Vivo and In Vitro.- Effect of TRH on 5'-deiodinases in Rat Pituitary Glands.- Perinatal Pituitary-thyroid Function at High Altitude.- Human Fetal Prolactin but not TSH Secretion is Affected by Dopaminergic Stimuli.- Cholinergic Agents and Inhibitors of Extracellular Calcium Influx Suppress the Secretion of TSH by Human Thyrotropic Adenoma Cells Maintained in Long-term Culture.- Comparison of a Pituitary TSH-secreting Micro- Versus Macroadenoma.- Defective TSH Suppression in a Case of Non-neoplastic Inappropriate TSH Secretion (ITSHS).- Thyrotropin Secretion in Thalassemic Patients During Puberty and Postpuberty.- Thyroid Function and Prolactin Secretion in Women with Menstrual Disorders and/or Infertility.- ?-adrenergic Control of TSH Secretion in Man.- TSH and Thyroidal Responses to Continuous and Intermittent TRH Administration.- Measurements of Thyrotropin-releasing Hormone (TRH)-like Immunoreactivity in Human Blood in Thyroid Diseases.- Immunoreactive TRH and TRH-OH in Rat Hypophysial Portal Blood.- Ontogeny of Human Pancreatic Thyrotropin-releasing Hormone.- Dopamine and L-Dopa, Precursors of Norepinephrine: Effects on Thyroxine Release.- Short-Term In Vitro Stimulatory Effect of Glucagon on T4 Secretion in Rat and Human Thyroid.- Effects of Phorbol Esters on Protein Phosphorylation and Free T3 Release by Mouse Thyroid Lobes.- Acute In Vitro Stimulatory Effect of Thyrotropin Releasing Hormone (TRH) on T4 Secretion in Rat and Human Thyroid.- Effect of Calmodulin Inhibitors on Thyroid Hormone Secretion.- Thyrotropic Activity of Acid Isoelectric Variants of Human Chorionic Gonadotropin from Trophoblastic Tumors.- Regulation of Thyroid Growth.- Effects of Neuropeptides and TSH on Thyroid Blood Flow and Hormone Secretion.- Effect of Protein Kinase C Activation on Thyroid Cell Growth and Function.- Control of Proliferation and Differentiation in Primary Cultures of Calf Thyroid Cells.- Growth Factor Requirement of Isolated Thyroid Follicles.- Production of Both Types of Insulin-Like Growth Factors by Primary Cultures of Ovine Thyroid Cells.- The Effect of Epidermal Growth Factor (EGF) on Thyroid Function in the Sheep and in Isolated Rat Hepatocytes.- Follicular Cells Culture.- Formation of Intracytoplasmic Microfollicular Lumina in Dispersed Thyroid Cells.- Different Calcium Requirements for Low Iodine Diet (LID) Induced Developmental Growth of the Rat Thyroid: Evidence from In Culture Experiments.- Effects of the Chronic and Acute Treatments of Pig Thyroid Cells with Forskolin on the Cyclic AMP Accumulation, the Phospholipid Turnover, and Iodination.- Regulatory Networks in the Acute Control of Thyroid Function.- Stimulation of Thyroid Adenylate Cyclase Activity in Sera of Patients with Nonthyroidal Illness.- Hormonal Regulation of DNA Polymerase ? Activity in Rat Thyroid Gland.- Norepinephrine and TSH Stimulation on Iodide Efflux in FRTL-5 Thyroid Cells Involves Metabolites of Arachidonic Acid and is Associated with the Iodination of Thyroglobulin.- Effect of TSH and Thyroid-stimulating Antibody (TSAb) on the Desensitization of the Adenylate Cyclase Activity in FRTL-5 Cells.- Regulation of HLA-DR Gene Expression in Cultured Human Thyroid Cells: A Role for Lectin, Gamma Interferon, and Cyclosporine.- Thyroid Hormone Structure and Metabolism.- Thyroid Hormone Structure-activity Relationships: An Unusual Conformation for 3,5,3'-triiodothyropropionic Acid.- Chromatographic Properties and Probable Structure of the Urinary Conjugate of an Ethane-1,2-diol Formed In Vivo from 3,5,3'-triiodothyronine (T3).- Effects of d-Propranolol Treatment on Transport of Thyroid Hormones into Tissue Cells.- Impaired Release of Hepatic Triiodothyronine (T3) in the Diabetic Low T3 Syndrome.- Metabolism of rT3 by Isolated Rat Hepatocytes.- Thyroid Hormone Metabolism in Kidney Epithelial Cells in Continuous Culture.- Extrathyroidal Conversion of Thyroxine to 3,5,3'-triiodothyronine in Rats Undergoing Acute Immobilization Stress.- Effect of Cadmium on Thyroid Hormone Metabolism.- Preferential Metabolism of T4 to rT3 (T3 Reverse) in Hyperthyroxinemia Induced by L-thyroxine (L-T4) Treatment of Hypothyroidism in Children and Adolescents.- NADPH with Cytosol Stimulates Deiodination by Detergentsolubilized Hepatic Microsomes: Evidence for NADPH-dependent Cytosolic Non-glutathione Reductase System.- The Ionic Microscope Enables the Visualization of Stable Iodine within Follicles of the Human Thyroid Gland.- Endocytosis of Organified Iodine in the Endostyle of the Amphioxus.- Thyroid Hormone Transport.- Human Hepatoma (HEP G2) Cells Secrete a Novel T4-binding Protein (27 K Protein).- Partial Purification of Rat Serum Thyroxine-binding Globulin.- Thyroid Function Tests in Subjects with a Genetic Isoelectric Focusing Variant TBG.- Effect of Long-chain Fatty Acids on the Binding of T4 and T3 to Human Thyroxine-binding Globulin (TBG).- An Unusual Type of Familial Dysalbuminemic Hyperthyroxinemia in a Japanese Family.- Peripheral Metabolism of Thyroid Hormones in Congenital Thyroid Hormone Transport Abnormalities: Familial Dysalbuminemic Hyperthyroxinemia and TBG Increase.- Free T4 Index Results are Non-specific in Patients with Hypothyroxinemia.- Measurement of "Free Thyroxine" in Dried Blood Samples on Filter Paper by Radio- and Enzyme-immunoassay for Monitoring Thyroid Function.- Effect of Dilution on FT3 and FT4 Concentration in Serum Containing Substances that Interact with Thyroid Hormone-binding Proteins.- Evidence for Dual Peripheral 5'deiodinases (5'D) Regulating Circulating T3 Levels in Man.- Evidence for Peripheral Autoregulation of Thyroxine Conversion.- Sites of T4 to T3 Conversion in the Rat.- Evaluation of Oleic Acid, Arachidonic Acid, and Various Drugs as Competitors for Serum Binding of Thyroxine.- Alterations in Thyroid Function Parameters Following Administration of Fatty Acids.- A New Form of X-chromosome Linked TBG Abnormality with no Demonstrable T4-binding Activity.- Normal Cellular Uptake of Thyroxine (T4) from Serum of Patients with Familial Dysalbuminemic Hyperthyroxinemia (FDH) or Elevated Thyroxine-binding Globulin (TBG): T4 Bound to Albumin is not Preferentially Transferred to Tissue.- Carrier-mediated Transport of Thyroid Hormone (TH) into Rat Hepatocytes is Rate Limiting in Total Cellular Uptake and Metabolism.- Enhanced Rate of Cellular Uptake of Thyroxine (T4) from Sera of Subjects with Familial Dysalbuminemic Hyperthyroxinemia (FDH).- Elevation of Sex Hormone Binding Globulin (SHBG) Levels in Some Sera with Inherited Increase in Thyroxine Binding Globulin (TBG).- Intrathyroidal Metabolism.- Identification and Regulation of Thyroperoxidase: Use of Specific Antiserum.- Irreversible Inactivation of Lactoperoxidase by Excess Hydrogen Peroxide Involving Cleavage of the Catalytic Heme Moiety.- Residual Capacity for Iodide Organification in Human Thyroid Slices Provoked by Hydrogen Peroxide.- T3 and rT3 Generation from Exogenous and Endogenous T4 in Perfused Dog Thyroids.- Effects of Synthetic Iodolipids on Thyroid Function "In Vitro": Possible Role in Thyroid Regulation.- Formation of Diiodotyrosine (DIT) by Ether-link Cleavage of T4 in Rat Liver Homogenate as Measured by DIT Radioimmunoassay.- Is Iodide Required for Peroxidase-catalyzed Coupling in Thyroglobulin?.- Inhibition of Thyroid Peroxidase (TPO) and Lactoperoxidase (LPO) by Goitrin and Ricinine.- Selective Inhibition by Monoamine Oxidase (MAO) Inhibitors of the Iodotyrosine Formation Induced by MAO Substrates in Bovine Thyroid Tissue.- Thyroid Function in Fasting Rats.- Insulin Deficiency Impairs Thyroid Peroxidase Activity: A Study in Experimental Diabetes Mellitus.- Thyroid Hormone Action.- On the Mechanism of Irreversible Brain Damage Caused by Perinatal Thyroid Hormone Deficiency.- Regulation of 19,000 Mr Soluble Protein and High Mobility Group Protein (HMG 14) Phosphorylation by Triiodothyronine (T3) in Primary Astrocytic Cultures.- Regulation by n-Butyrate of Thyroid Hormone Receptor Levels in Cultured Cells of Glial Origin.- Inhibitory Effect of Thyroid Hormone on Protein Synthesis by Fetal Rat Neurons in Primary Culture.- Effects of T3 and Dexamethasone on Proliferation and Enzyme Activities of Glial Cells in Culture.- Healing Effects of Iodine and Thyroid Hormone on Experimental Rickets.- Thyroid Hormone Stimulates Red Blood Cell Ca++-dependent ATPase Activity Through a "Non-Hormonal" Effect.- Induction of Metamorphosis and Thyroid Function in the Larval Lamprey.- Differential Effect of Hypothyroidism on the Dendritic Density of Pyramidal Neurons of the Cerebral Cortex.- Prostacyclin (PGI2) Production in Hyperthyroid Rats and Patients with Graves' Disease.- Regulation of Rat Liver Glycerophospholipid Fatty Acid Composition in Hypo- and Hyperthyroidism.- Effect of Thyroxine Replacement Therapy on Serum Thyrotropin.- Thyroxine-induced Molting and Gonadal Functions of Laying Hens.- Glucagon Causes Disappearance of a T3 and Carbohydrate-inducible Rat Hepatic mRNA (mRNAS14): Unexpected Circadian Dependency of Response.- Suppression of Triiodothyronine-induced Growth Hormone Gene Expression by Insulin-like Growth Factor-I in Thyroidectomized Rat Pituitary Cells.- Hypothyroidism Inhibits the Rapid Response of mRNA-S14 to Carbohydrate Feeding.- Thyroid Hormone Stimulates Alkaline Phosphatase Activity in Cultured Osteoblastic Cells with T3 Nuclear Receptors.- Studies on the Effects of Thyroid Hormones and their Metabolites on Human Red Cell Acetylcholine Esterase.- Thyroid Hormone Receptors.- Evidence for Nuclear T3 Receptors in Neonatal Cerebral Astrocytes.- Direct Thyroid Hormone Stimulation of Mitochondrial Oxidative Phosphorylation: The Role of Adenine Nucleotide Translocase (AdNT).- Induction of Liver Mitochondrial ?-Glycerophosphate Dehydrogenase (?-GPD) by Glucocorticoid Deficit: Role of the Nuclear T3-receptor (nT3-R).- Ontogeny of Nuclear T3 Receptor in Primary Cultured Astrocytes.- Purification and Characterization of T3-receptor from Beef Liver Plasma Membrane.- Effect of the Thyroid Status on the Properties of the ?-receptors of Adipocytes as Related to Lipolysis.- Receptor Induction by Thyroid Hormones in Tadpole Erythrocytes In Vivo and In Vitro.- Putative Nuclear Triiodothyronine Receptors in Tadpole Liver During Metamorphic Climax.- Activity of T3-responsive ?-Glycerophosphate Dehydrogenase (?-GPD) and the Characteristics of Nuclear T3-binding in the Male and Female Rat.- Role of T4 in the Modulation of Pituitary T3 Nuclear Receptors (T3nR) in Hypothyroid Rats.- Human Nuclear Thyroid Hormone Receptors.- Ontogeny of Thyroid During Embryogenesis: Evidence of Two Thyroxine Binding Sites.- Tissue Deiodination of Thyroid Hormone.- Insulin, Glucose, and Glucagon are Potential Modulators of Thyroid Hormone Action through Brown Adipose Tissue 5'-deiodinase in Rats.- Effect of Thyroid Hormones, Food Deprivation, and Cold Exposure on Thyroid T4 Outer Ring Monodeiodinating Activity (5'MDI) in Mice.- 3,3',5'-triiodothyronine (rT3) Inhibits Iodothyronine5'-deiodinating Activity Induced by Equimolar Concentration of 3,5,3'-triiodothyronine (T3) in Cultured Fetal Liver of Mouse.- Design of Active Site-directed Iodothyronine Deiodinase Ligands Using TBPA as a Binding Site Model.- Generated Dihydrolipoamide and Cytosolic Components Stimulate Hepatic Microsomal Thyroxine 5'-deiodination: Similar Effects of Cytosolic Components on Other Sulfhydryl Compounds.- Characteristics of T4 Inner Ring Deiodinase in the Liver, Kidney, and Cerebral Cortex of Rat: Two Kinds of Isoenzymes.- Inhibition of T4 5'-deiodinase in Human Placental Cells by Cyclic-AMP, Butyrate, and Calcium.