Goodman and Gilman's The Pharmacological Basis of Therapeutics, Twelfth Edition

Editor: Laurence L. Brunton, PhD Professor of Pharmacology and Medicine University of California San Diego School of Medicine La Jolla, CA Associate Editors: Bruce A. Chabner, MD Clinical Director MDF Cancer Center Professor of Medicine Harvard Medical School Boston, MA Bjorn Christian Knollmann, MD, PhD Associate Professor of Medicine and Pharmacology Oates Institute for Experimental Therapeutics Vanderbilt University School of Medicine Division of Clinical Pharmacology Nashville, TN

Contributors

Consultants to the Editors

Preface

Preface to the First Edition

SECTION I: GENERAL PRINCIPLES

1. Drug Invention and the Pharmaceutical Industry, Suzanne M. Rivera and Alfred Goodman Gilman

2. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination, Iain L. O. Buxton and Leslie Z. Benet

3. Pharmacodynamics: Molecular Mechanisms of Drug Action, Donald K. Blumenthal and James C. Garrison

4. Drug Toxicity and Poisoning, Kevin C. Osterhoudt and Trevor M. Penning

5. Membrane Transporters and Drug Response, Kathleen M. Giacomini and Yuichi Sugiyama

6. Drug Metabolism, Frank J. Gonzalez, Michael Coughtrie, and Robert H. Tukey

7. Pharmacogenetics, Mary V. Relling and Kathleen M. Giacomini

SECTION II: NEUROPHARMACOLOGY

8. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems, Thomas C. Westfall and David P. Westfall

9. Muscarinic Receptor Agonists, Joan Heller Brown and Nora Laiken

10. Anticholinesterase Agents, Palmer Taylor

11. Agents Acting at the Neuromuscular Junction and Autonomic Ganglia, Ryan E. Hibbs and Alexander C. Zambon

12. Adrenergic Agonists and Antagonists, Thomas C. Westfall and David P. Westfall

13. 5-Hydroxytryptamine (Serotonin) and Dopamine, Elaine Sanders-Bush and Lisa Hazelwood

14. Neurotransmission and the Central Nervous System, Perry B. Molinoff

15. Drug Therapy of Depression and Anxiety Disorders, James M. O'Donnell and Richard C. Shelton

16. Pharmacotherapy of Psychosis and Mania, Jonathan M. Meyer

17. Hypnotics and Sedatives, S. John Mihic and r. Adron Harris

18. Opioids, Analgesia, and Pain Management, Tony L. Yaksh and Mark S. Wallace

19. General Anesthetics and Therapeutic Gases, Piyush M. Patel, Hemal H. Patel, and David M. Roth

20. Local Anesthetics, William A. Catteral nad Kenneteh Mackie

21. Pharmacotherapy of the Epilepsies, James O. McNamara

22. Treatment of Central Nervous System Degenerative Disorders, David G. Standaert and Erik D. Roberson

23. Ethanol and Methanol, Marc A. Schuckit

24. Drug Addition, Charles P. O'Brien

SECTION III: MODULATION OF CARDIOVASCULAR FUNCTION

25. Regulation of Renal Function and Vascular Volume, Robert F. Reilly and Edwin K. Jackson

26. Renin and Angiotensin, Randa Hilal-Dandan

27. Treatment of Myocardial Ischemia and Hypertension, Thomas Michel and Brian B. Hoffman

28. Pharmacotherapy of Congestive Heart Failure, Bradley A. Maron and Thomas P. Rocco

29. Anti-Arrhythmic Drugs, Kevin J. Sampson and Robert S. Kass

30. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs, Jeffrey I. Weitz

31. Drug Therapy for Hypercholesterolemia and Dyslipiedmia, Thomas P. Bersot

SECTION IV: INFLAMMATION, IMMUNOMODULATION, AND HEMATOPOIESIS

32. Histamine, Bradykinin, and Their Antagonists, Randal A. Skidgel, Allen P. Kaplan, and Ervin G. Erdös

33. Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor, Emer M. Smyth, Tilo Grosser, and Garret A. Fitzgerald

34. Anti-inflammatory, Antipyretic, and Analgesic Agents; Pharmacology of Gout, Tilo Grosser, Emer Smyth, and Garret A. FitzGerald

35. Immunosupressants, Tolerogens, and Immunostimulants, Alan M. Krensky, William M. Bennett, and Flavio Vincenti

36. Pulmonary Pharmacology, Peter J. Barnes

37. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins, Kenneth Kaushansky and Thomas J. Kipps

SECTION V: HORMONES AND HORMONE ANTAGONISTS

38. Introduction to Endocrinology: The Hypothalamic-Pituitary Axis, Keith L. Parker and Bernard P. Schimmer

39. Thyroid and Anti-Thyroid Drugs, Gregory A. Brent and Ronald J. Koenig

40. Estrogens and Progestins, Ellis R. Levin and Stephen R. Hammes

41. Androgens, Peter J. Snyder

42. ACTH, Adrenal Steroids, and Pharmacology of the Adrenal Cortex, Bernard P. Schimmer and John W. Funder

43. Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia, Alvin C. Powers and David D'Alessio

44. Agents Affecting Mineral Ion Homeostatis and Bone Turnover, Peter A. Friedman

SECTION VI: DRUGS AFFECTING GASTROINTESTINAL FUNCTION

45. Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease, John L. Wallace and Keith A. Sharkey

46. Treatment of Disorders of Bowel Motility and Water Flux: Anti-Emetics; Agents Used in Biliary and Pancreative Disease, Keith A. Sharkey and John L. Wallace

47. Pharmacotherapy of Inflammatory Bowel Disease, John L. Wallace and Keith A. Sharkey

SECTION VII: CHEMOTHERAPY OF MICROBIAL DISEASES

48. General Principles of Antimicrobial Therapy, Tawanda Gumbo

49. Chemotherapy of Malaria, Joseph M. Vinetz, Jerome Clain, Viengngeun Bounkeua, Richard T. Eastman, and David Fidock

50. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections, Margaret A. Phillips, Samuel L. Stanley, Jr.

51. Chemotherapy of Helminth Infections, James McCarthy, Alex Loukas, and Peter J. Hotez

52. Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections, William A. Petri, Jr.

53. Penicillins, Cephalosporins, and Other ß-Lactam Antibiotics, William A. Petri, Jr.

54. Aminoglycosides, Conan MacDougall and Henry F. Chambers

55. Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents, Conan MacDougall and Henry F. Chambers

56. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy, Tawanda Gumbo

57. Antifungal Agents, John E. Bennett

58. Antiviral Agents (Nonretroviral), Edward P. Acosta and Charles Flexner

59. Antiretroviral Agents and Treatment of HIV Infection, Charles Flexner

SECTION VIII: CHEMOTHERAPY OF NEOPLASTIC DISEASES

60. General Principles of Cancer Chemotherapy, Bruce A. Chabner

61. Cytotoxic Agents, Bruce A. Chabner, Joseph Bertino, James Cleary, Taylor Ortiz, Andrew Lane, Jeffrey G. Supko, and David Ryan

62. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines, Bruce A. Chabner, Jeffrey Barnes, Joel Neal, Erin Olson, Hamza Mujagic, Lecia Sequist, Wynham Wilson, Dan L. Longo, Constantine Mitsiades, and Paul Richardson

63. Natural Products in Cancer Chemotherapy: Hormones and Related Agents, Beverly Moy, Paul Goss, Richard J. Lee, and Matthew Smith

SECTION IX: OPHTHALMOLOGY

64. Ocular Pharmacology, Jeffrey D. Henderer and Christopher J. Rapuano

65. Dermatological Pharmacology, Craig Burkhart, Dean Morrell, and Lowell Goldsmith

66. Contraception and Pharmacotherapy of Obstetrical and Gynecological Disorders, Bernard P. Schimmer and Keith L. Parker

67. Environmental Toxicology: Carcinogens and Heavy Metals, Michael C. Byrns and Trevor M. Penning

APPENDICES

I. Principles of Prescription Order Writing and Patient Compliance, Iain L.O. Buxton

II. Design and Optimization of Dosage Regimens: Pharmacokinetic Data, Kenneth E. Thummel, Danny D. Shen, and Nina Isoherranen

Index