Hyperthermia in Oncology - Principles and Therapeutic Outlook

1.Principles of Hyperthermia14
1.1.Definition of Hyperthermia (Manfred Schmidt)14
1.1.1.Different Temperature Regimes14
1.1.2.Heating Techniques15
1.1.3.References15
1.2.Physical Basics and Hyperthermia Applications (Manfred Schmidt)15
1.2.1.Electromagnetic Irradiation15
1.2.2.Interaction of Non-Ionizing Electromagnetic Radiation with Matter16
1.2.3.Practical Realizations18
1.2.4.Planning and Optimization21
1.2.5.Harmful Effects of Non-Ionizing Radiation22
1.2.6.Further Heating Techniques22
1.2.7.Heat Transport23
1.2.8.References23
1.3.Biological Rationale of Hyperthermia (Udo S. Gaipl, Petra Schildkopf, Valeria Milani)23
1.3.1.Biological Rationale and Mode of Action of Hyperthermia (HT)23
1.3.2.Interaction of Hyperthermia (HT) and Chemotherapeutic Agents24
1.3.3.Interaction of Hyperthermia (HT) and Ionizing Radiation (RT)25
1.3.4.Immune Modulation by Hyperthermia26
1.3.5.References27
2.Techniques, Clinical Use and Quality Assurance30
2.1.Hyperthermia Treatment Techniques (Oliver J. Ott, Andreas Jordan, Lars H. Lindner)30
2.1.1.Classical Techniques30
2.1.2.New Developments32
2.1.3.References33
2.2.Practical Recommendations (Sultan Abdel-Rahman, Tungte Wang, Margareta Santl, Lars H. Lindner)35
2.2.1.Treatment Planning37
2.2.2.Treatment37
2.2.3.Treatment Documentation38
2.2.4.Requirements and Characterization of Equipment38
2.2.5.Safety Aspects39
2.2.6.Hyperthermia Staff Requirements39
2.2.7.References39
2.3.Quality Assurance (Johanna Gellermann)39
2.3.1.Heat Dosimetry39
2.3.2.Thermometry and Verification40
2.3.3.Hyperthermia Treatment Planning42
2.3.4.Future Aspects44
2.3.5.References44
3.Clinical Results of Quality-Assured Hyperthermia48
3.1.Hyperthermia as Sole Modality (Oliver J. Ott)48
3.2.Chemotherapy and Hyperthermia (Rolf D. Issels, Lars H. Lindner)48
3.2.1.References49
3.3.Radiotherapy and Hyperthermia (Oliver J. Ott)50
3.3.1.Breast Cancer51
3.3.2.Rectal Cancer52
3.3.3.Cervical Carcinoma53
3.3.4.Further Results54
3.3.5.References54
3.4.Radiochemotherapy and Hyperthermia (Oliver J. Ott)55
3.4.1.Rectal Cancer55
3.4.2.Anal Cancer55
3.4.3.Esophageal Carcinoma56
3.4.4.Further Fields of Research56
3.4.5.References56
4.The Role of Hyperthermia in Pediatric Oncology (Rüdiger Wessalowski)60
4.1.Indications60
4.2.Locoregional Hyperthermia in Children and Adolescents60
4.2.1.Application of Hyperthermia and Thermometry60
4.2.2.Analysis of Temperatures62
4.2.3.Hyper-PEI Treatment Schedule62
4.3.Limitations63
4.4.Results64
4.4.1.Experimental Studies64
4.4.2.Clinical Studies65
4.5.Perspectives68
4.5.1.Technical Approach68
4.5.2.Clinical Aspects69
4.6.References69
5.Current and Future Clinical Trials (Rolf D. Issels, Oliver J. Ott)72
5.1.Chemotherapy and Hyperthermia72
5.2.Radiotherapy and Hyperthermia73
5.3.References75
6.Summary (Oliver J. Ott, Rolf D. Issels, Rüdiger Wessalowski)78
Index79