Evidence-Based Gastroenterology and Hepatology

John McDonald, Professor of Gastroenterology at the University of Ontario, London Ontario, Coordinating Editor in the Cochrane Collaboration Steering Committee on methodology, and Past President of the Canadian College of Gastroenterology Professor Andrew Burroughs MBChB Hons FRCP Consultant Physician and Hepatologist, Royal Free Hospital, London, has an international reputation as a clinical and academic Hepatologist and has published widely in all areas of liver disease. He is a full time clinician and has been awarded a personal chair, as Professor of Hepatology in the University of London. Brian Feagan is Professor of Medicine and Epidemiology and Biostatistics at the University of Western Ontario. He holds cross-appointments in the Divisions of Internal Medicine, Clinical Pharmacology and Gastroenterology. He is a specialist in Internal Medicine with training in Clinical Epidemiology and Gastroenterology who has been the lead investigator in the design and implementation of randomized controlled trials since 1986. In addition to being an internationally recognized expert in the therapy of Inflammatory Bowel Disease, Dr. Feagan has conducted trials on behalf of Industry and peer-reviewed agencies in a wide range of disease states. Dr. Feagan is interested in the evaluation of Health Related Quality of Life (HRQL) and has performed research on the operating properties of HRQL instruments.

Contributors. 1 Introduction (John WD McDonald, Andrew Burroughs, Brian, G Feagan and M Brian Fennerty). Part I: Gastrointestinal disorders. 2 Gastroesophageal refl ux disease (Naoki Chiba and M Brian Fennerty). 3 Barrett's esophagus (Constantine A Soulellis, Marc Bradette, Naoki Chiba, M Brian Fennerty and Carlo A Fallone). 4 Esophageal motility disorders: Achalasia and spastic motor disorders (Jason R Roberts, Marcelo F Vela and Joel E Richter). 5 Eosinophilic esophagitis (Elizabeth J Elliott). 6 Ulcer disease and Helicobacter pylori infection: Etiology and treatment (Naoki Chiba). 7 Non-steroidal anti-infl ammatory drug-induced gastro-duodenal toxicity (Alaa Rostom, Katherine Muir, Catherine Dube, Emilie Jolicoeur, Michel Boucher, Peter Tugwell and George Wells). 8 Acute non-variceal gastrointestinal hemorrhage: Treatment (Nicholas Church and Kelvin Palmer). 9 Functional dyspepsia (Sander Veldhuyzen van Zanten). 10 Celiac disease: Diagnosis, treatment and prognosis (James Gregor and Michael Sai Lai Sey). 11 Crohn's disease (Brian G Feagan and John WD McDonald). 12 Ulcerative colitis (Derek P Jewell, Lloyd R Sutherland, John WD McDonald and Brian G Feagan). 13 Pouchitis after restorative proctocolectomy (Darrell S Pardi and William J Sandborn). 14 Microscopic colitis: Collagenous and lymphocytic colitis (Johan Bohr, Robert Lofberg and Curt Tysk). 15 Drug-induced diarrhea (Bincy P Abraham and Joseph H Sellin0. 16 Metabolic bone disease in gastrointestinal disorders (Ann Cranney, Alaa Rostom, Catherine Dube, Rachid Mohamed, Peter Tugwell, George Wells and John WD McDonald). 17 Colorectal cancer in ulcerative colitis: Surveillance (Paul Collins, Bret A Lashner and Alastair JM Watson). 18 Colorectal cancer: Population screening and surveillance (Theodore R Levin and Linda Rabeneck). 19 Prevention and treatment of travelers' diarrhea (Herbert L DuPont). 20 Clostridium diffi cile associated disease: Diagnosis and treatment (Lynne V McFarland and Christina M Surawicz0. 21 Irritable bowel syndrome (Alexander C Ford, Paul Moayyedi and Nicholas J Talley). 22 Ogilvie's syndrome (Michael D Saunders). 23 Gallstone disease (Laura VanderBeek, Calvin HL Law and Ved R Tandan). 24 Acute pancreatitis (Colin D Johnson and Hassan Elberm). 25 Obesity management: Considerations for the gastroenterologist (Leah Gramlich, Marilyn Zeman and Arya M Sharma). Part II: Liver disease. 26 Hepatitis C (Keyur Patel, Hans L Tillmann and John G McHutchison). 27 Hepatitis B: Prognosis and treatment (Piero Luigi Almasio, Calogero Camma, Vito Di Marco and Antonio Craxi). 28 Alcoholic liver disease (Helene Castel and Philippe Mathurin). 29 Non-alcoholic fatty liver disease (Christopher P Day). 30 Hemochromatosis (Gary P Jeffrey and Paul C Adams). 31 Wilson's disease (James S Dooley and Aftab Ala). 32 Primary biliary cirrhosis (Gideon M Hirschfi eld and E Jenny Heathcote). 33 Autoimmune hepatitis (Michael MP Manns and Arndt Vogel). 34 Primary sclerosing cholangitis (Nishchay Chandra, Susan N Cullen and Roger W Chapman). 35 Non-histological assessment of liver fi brosis (Dominique Thabut and Marika Simon-Rudler). 36 Portal hypertensive bleeding (Christos Triantos, John Goulis and Andrew K Burroughs). 37 Hepatic outfl ow syndromes and splanchnic venous thrombosis (Marco Senzolo, Neeral Shah, David Patch and Stephen Caldwell). 38 Ascites, hepatorenal syndrome and spontaneous bacterial peritonitis (Pere Gines, Andres Cardenas, Vicente Arroyo and Juan Rodes). 39 Hepatic encephalopathy: Treatment (Peter Ferenci and Christian Muller). 40 Hepatocellular carcinoma (Massimo Colombo and Massimo Iavarone). 41 Fulminant hepatic failure: Treatment (James O'Beirne, Nick Murphy and Julia Wendon). 42 Liver transplantation: Prevention and treatment of rejection (Maria Pleguezuelo, Giacomo Germani and Andrew K Burroughs). 43 Liver transplantation: Prevention and treatment of infection (Antoni Rimola and Miquel Navasa). 44 Management of HCV infection and liver transplantation (Brett E Fortune, Hugo R Rosen and James R Burton, Jr). 45 Management of HBV infection and liver transplantation (Evangelos Cholongitas and George V Papatheodoridis). 46 Liver biopsy (Evangelos Cholongitas, Andrew K Burroughs and Amar P Dhillon). 47 Drug induced liver disease: Mechanisms and diagnosis (Raul J Andrade and M Isabel Lucena). Index. The colour plate section.