Management of Myocardial Reperfusion Injury

Preface.- Introduction.- Myocardial reperfusion injury: The clinical importance and magnitude of the problem, JC Kaski and G Ambrosio.- Section I. Myocardial reperfusion injury - Pathophysiology and molecular mechanisms.-  The "no-reflow phenomenon" leading to myocardial injury and dysfunction- Consequences of reperfusion injury: Pathophysiology and molecular basis, H M Piper.- The coronary microcirculation expert’s view, A Pries.- The pathologist’s view, R Virmani.- The interventionist’s view.- Commonly asked questions.- Pathophysiology and molecular mechanisms - Established facts and future research avenues – An integrated view, D Yellon.- Section II. Diagnosis.- The electrocardiogram.- Biomarkers.- Angiography.- Echocardiography.- MRI.- SPECT.- PET, P Camici.- Commonly asked questions.- An integrated view on diagnostic strategies – Identifying salvageable myocardium.- Diagnostic algorithms.- Section III. Management – Currently available tools and future perspectives.- An integrated view on management – What is effective and what is not.- Discrepancies between results of treatment in experimental models and patients. Management algorithms, B Gersh.- Catheter lab options, M Marzilli.- Myocardial protection – Metabolic issues, WC Stanley.- Myocardial protection – Preconditioning.- New pharmacological options.- Assessment of treatment efficacy.- Commonly asked questions.- Future perspectives, JC Kaski, D Yellon and B Gersch.