Melanocytic Proliferations

Cynthia M. Magro, MD, is Professor of Pathology and Director of Dermatopathology at Weill Medical College of Cornell University in New York City. She has published extensively in the areas of inflammatory skin disease, including collagen vascular disease, vasculitis, cutaneous manifestations of systemic disease, and unique drug hypersensitivity reactions. A significant focus of her work has been lymphocytic infiltrates, including unique forms of drug reactions such as the interstitial granulomatous drug reaction and drug-associated reversible T cell dyscrasia; prelymphomatous cutaneous lymphoid dyscrasias including atypical lymphocytic lobular panniculitis pityriasis lichenoides chronica and pigmented purpuric dermatosis; and malignant T and B cell lymphomas. She has extended her work in immune mechanisms of skin disease and applied it to areas of lung transplantation and pulmonary fibrosis. Neil Crowson, MD, is Clinical Professor of Dermatology, Pathology, and Surgery, and Director of Dermatopathology at the University of Oklahoma and Regional Medical Laboratory in Tulsa, Oklahoma. His current research interests focus on mechanisms of neoplastic and inflammatory skin disease. Martin C. Mihm, Jr., MD, is Clinical Professor of Pathology and Dermatology at Harvard Medical School, Massachusetts General Hospital. He is internationally recognized for his expertise in the pathology, diagnosis, and management of pigmented lesions, lymphoid disorders, and vascular tumors. He has worked extensively to understand the host response to melanoma and other tumors. He has served as codirector of the WHO Melanoma Program in addition to his many obligations in translational and clinical research in cutaneous inflammation, tumor vaccination, and pathogenesis of vascular lesions in children.

Dedication, vii

Preface, viii

Disclosure, ix

About the Companion Website, x

1 An Approach to the Clinical Diagnosis of Melanoma, Its Precursors, and Its Clinical Mimics, 1

2 Freckles and Lentigines, 44

3 Benign Acquired Nevi, 65

4 Dermal Dendritic Melanocytic Proliferations/Dermal Melanocytoses, 85

5 Spitz Nevus, 107

6 Combined Nevus, Deep Penetrating Nevus, Plexiform Spindle Cell Nevus, and Borderline Tumors of the Deep Penetrating Nevus Variant, 164

7 Recurrent Melanocytic Nevus, 175

8 Congenital Nevi, 187

9 Dysplastic Melanocytic Nevi, De Novo Intradermal Epithelioid and Lentiginous Melanocytic Dysplasias, and Nevi at Specific Anatomic Sites, 201

10 Melanoma, 254

11 Conjunctival Melanocytic Proliferations, 365

12 Use of Adjunctive Immunoperoxidase, Molecular, and Ultrastructural Studies in the Diagnosis of Melanocytic Proliferations, 380

13 Biology of Melanoma, 412

14 Borderline Melanocytic Proliferation, 443

15 Dermatoscopic Diagnosis of Melanoma, 467

16 Reflectance Confocal Microscopy, 474

17 Therapy of Melanoma, 488

Index, 510