Osteoporosis in Men

Professor of Medicine and Director, Clinical Research Center, Division of Endocrinology, Diabetes and Clinical Nutrition, Oregon Health & Science University, Portland, Oregon John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians & Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700. Professor of Medicine, Division of Endocrinology, Department of Internal Medicine, UZ Gasthuisberg, Leuven, Belgium

Section 1 Essentials of bone biology 1. The Biochemistry of Bone: Composition and Organization 2. Bone Remodeling: Cellular Activities in Bone 3. Assessment of Bone Turnover Using Biochemical Markers 4. Fundamentals of Mineral Homeostasis 5. The Mechanical Properties of Bone 6. Assessment of Bone Architecture

Section 2 Development and growth of the male skeleton 7. Skeletal Growth in Males 8. Pubertal Growth of the Male Skeleton 9. The Effects of Sex Steroids on Bone Growth 10. Nutritional Basis of Skeletal Growth 11. Physical Activity and Skeletal Growth

Section 3 Skeletal genetics 12. The Genetics of Peak Bone Mass

Section 4 Aging and the male skeleton 13. Age-Related Changes in Bone Remodeling and Micro Architecture 14. Markers of Bone Remodeling and the Aging Skeleton 15. Alterations in Mineral Metabolism in the Aging Male 16. Change in Bone Size and Geometry with Aging 17. Aging and Bone Density 18. The Effect of Age on Material Properties

Section 5 Nutritional issues 19. Calcium, Bone Strength and Fractures 20. Vitamin D and Bone 21. Role of Dietary Protein in Bone Growth and Bone Loss

Section 6 Sex steroids and the skeleton in men 22. The Molecular Biology of Sex Steroids in Bone: Similarities and Differences Among the Sexes 23. Estrogen and the Skeleton – Rodents 24. Estrogen and the Skeleton – Humans 25. Androgens and the Skeleton – Animal Models 26. Androgens and the Skeleton – Humans 27. Androgen Effects on the Skeletal Muscle

Section 7 Fractures in men 28. Epidemiology of Fractures 29. Individualized Progress of Fractures in Men 30. Physical Activity, Physical Function and Fall and Fracture Risk in Older Men 31. Economic Impact of Osteoporotic Fractures (vs women) 32. Adverse Health Outcomes in Men with Osteoporosis

Section 8. Metabolic bone disease in men 33. Idiopathic Osteoporosis 34. Glucocorticoid Induced Osteoporosis 35. Testicular Dysfunction 36. Alcohol and Bone 37. Transplantation Osteoporosis 38. Management of Fractures in Men with Impaired Renal Function 39. Hyperparathyroidism 40. Hypercalciuria 41. The Skeletal Phenotype of the Male Athlete 42. Inherited and Related Disorders of Bone Matrix Synthesis in Men

Section 9 Diagnostic approach 43. Dual-Energy X-ray Absorptiometry (DXA) in Men 44. Quantitative Ultrasound Diagnosis of Osteoporosis in Men 45. Advanced Structural Assessment of Bone Using CT and MRI 46. Vertebral Fracture Assessments 47. The Use of Bone Biopsies in the Diagnosis of Male Osteoporosis 48. Overall diagnostic strategy

Section 10 Therapy 49. Diagnostic Thresholds for Osteoporosis in Men 50. Cost-Effectiveness of Interventions to Reduce Osteoporosis-Related Fractures in Men: Current Data, Controversies, and Challenges 51. Nutritional Therapy for Skeletal Health in Men 52. Exercise Programs for Patients with Osteoporosis 53. Calcitonin: History, Physiology, Pathophysiology and Therapeutic Applications 54. Treatment of Male Osteoporosis with Bisphosphonates 55. Treatment of Male Osteoporosis with Parathyroid Hormone 56. Testosterone Therapy for Osteoporosis in Men 57. Future Therapies: Strontium, SERMs, SARMs and New Therapies on the Horizon