Cell Determination During Hematopoiesis

Geoffrey Brown is Reader in Cellular Immunology at the College of Medical and Dental Sciences at the University of Birmingham, UK and Director of the EU-funded Marie Curie FP7 Initial Training Network and consortium DECIDE (Decision-making within cells and differentiation entity therapies). He received a BSc in microbiology from Queen Elizabeth College, University of London and a PhD in tumour biology from University College, London. Postdoctoral research was at the MRC Immunochemistry Unit, Oxford and the Nuffield Department of Clinical Medicine, Oxford. At Oxford, Geoffrey was also the IBM Fellow, University of Oxford and Research Lecturer of the House, Christ Church College. His early work described human B and T lymphocyte antigens leading to the discovery of the common acute lymphoblastic leukaemia antigen (CD10). This led to designation of the childhood leukaemia as common acute lymphoblastic leukaemia (cALL). His research for many years has concerned the development of blood cells and Geoffrey has proposed the pair-wise model for blood cell development.

Foreword; Gene regulatory networks directing cell fates within the hematopoietic system; Lymphoid and myeloid lineage commitment of multipotent hematopoietic progenitors; Intracellular signaling for granulocytic and monocytic differentiation; Dendritic cell development, lineage issues and haematopoiesis at the single cell level; The making and breaking of a B Lymphocyte; Developmental pathways and molecular regulation of early T cell development in mouse and human; Development of natural killer cell diversity; Thymic epithelial cell development and function; The biology of lymphoid tissue inducer cells; A pair-wise relationships model of hematopoietic fate determination; The epigenetics of haematopoiesis; Index.