Bone Cancer

Dominique Heymann studied cell biology, biochemistry and immunology in INSERM (French NIH) unit 211 at the University of Nantes and received his Ph.D. in 1995. He was appointed Associate Professor in 2001 in the Department of Histology and Embryology. In 2009, he was awarded a personal Chair of Histology and Embryology.Currently he is the Quality Control Manager of the Tissue Bank and Gene and Cellular Therapy Unit at Nantes Hospital. He heads a laboratory research group (INSERM UMR 957) of 65 people at the Faculty of Medicine, where the pathogenesis of primary bone tumours, and more specifically, the role of bone microenvironment (osteoclasts, mesenchymal stem cells, OPG/RANK/RANKL, IL-6 and MCSF cytokine family) in tumour growth is studied.In 2006, Dominique Heymann won the Paul Mathieu prize from the National Academy of Medicine for his work entitled “From the osteolytic process associated to primary bone tumors to the development of bi-therapies for osteosarcoma”. He was on the national scientific advisory board of INSERM (2008-2012) and is now Co-Chairman of INSERM scientific commission n°5 (“Physiology and pathophysiology of endocrine, bone, skin and gastrointestinal tissues”). He has authored approximately 180 publications in peer- reviewed journals, more than 300 abstracts and 20 book chapters. He is also Associate Editor of Life Sciences, Academic Editor of PLoS ONE, Editor-in-Chief of the Open Bone Journal and serves on the Editorial Board of Current Medicine Chemistry, European Journal of Pharmacology, and Journal of Bone Oncology.

Section 1: Introduction Genetic control, frequencies and epidemiology of bone cancers The incidence and progression of metastatic bone lesions Section 2: Bone microenvironment and bone cancer Bone microenvironment and tumor growth Osteoblast Differentiation and Cell Signalling Osteoclast Differentiation and FunctionCytokines in bone remodeling and bone tumors Proteases and bone tumors - therapeutic approaches Section 3: Bone markers Early bone metastasis Bone remodeling markers and bone cancer Proteomic of bone cancers Genomic Alterations in Bone Tumors Biology of bone tumors and new diagnostic tools Gene profiling of osteosarcoma Molecular pathology of osteosarcomaHistopathology of prostate and breast metastasesTechnical aspects: how do we best prepare bone samples for proper histological analysis?Section 4: Myeloma, odontogenic tumors and bone metastases Multiple myeloma bone diseasesOsteolytic lesionsBone metastases of prostatic cancer Bone metastases of breast cancer Section 5: Primary bone tumors Osteosarcoma and osteoblasts: diagnosis and therapy Ewing sarcoma family of tumors: diagnosis and therapyNon-surgical treatment of chondrosarcoma: diagnosis and therapyChondrosarcoma of bone: diagnosis and therapy Osteoclast-rich lesions of bone: diagnosis and therapy Section 6: Imaging of bone cancers Interventional Radiologic TechniquesImaging of bone metastases Diagnosis of bone metastases Section 7: Pain control in bone cancers Pain control with radiotherapyMechanisms and management of bone cancer pain Malignant skeletal painSection 8: New therapeutic advances of bone cancers Primary bone tumors and novel therapeutic approaches Cytokine gene therapy in bone remodeling BisphosphonatesMulti-targeted approachRANKL and targeted therapy Apoptosis and drug resistance