Metal Complex–DNA Interactions

Nikolaos Hadjiliadis is Professor in the Dept of Chemistry at the University of Ioannina, Greece. Einar Sletten is Professor in the Dept of Chemistry at the University of Bergen, Norway.

A Basic Structural and Kinetic Aspects 1. Sequence-Selective Binding of Transition Metal Complexes to DNA 2. Thermodynamic Models of Metal Ion -DNA.Interactions 3. Metal Ion Coordination in G-quadruplexes 4. Supramolecular Chemistry of Metal-Nucleobase Complexes B Medical Applications 5. Platinum Drugs, Nucleotides, and DNA: the Role of Interligand Interactions, nucleotides and DNA 6. Role of DNA Repair in Antitumor Effects of Platinum Drugs 7. Telomeres and Telomerase: Potential Targets for Platinum Complexes 8. Toward Photodynamic Therapy of Cancer with Platinum Group Metal Polyazine Complexes 9. Platinated Oligonucleotides: Synthesis and Applications for the Control of Gene Expression 10. New Titanium and Ruthenium Anticancer Drugs and their Interaction with DNA C DNA-Recognition - Nucleases and Sensors 11. Groove-Binding Ruthenium(II) Complexes as Probes of DNA Recognition 12. DNA Recognition and Binding by Peptide-Metal Complex conjugate 13. Artificial Restriction Agents - Hydrolytic Agents for DNA Cleavage 14. New Metallo-DNAzymes: Fundamental Studies of Metal-DNA Interactions and Metal Sensing Applications 15. Two-metal Ion Dependent Catalysis in Nucleic Acid Enzymes D Toxicological aspects 16. Mercury- DNA Interactions. Structural Studies on Mercury II -Mediated T-T Base-Pair with NMR Spectroscopy 17. Chromium-Induced DNA Damage and Repair 18. Arsenic and nickel: Mechanisms Affecting DNA Integrity