Structural Genomics, Part B -

Structural Genomics, Part B

Andrzej Joachimiak (Herausgeber)

Buch | Hardcover
112 Seiten
2009
Academic Press Inc (Verlag)
978-0-12-374442-5 (ISBN)
137,15 inkl. MwSt
Structural genomics is the systematic determination of 3-dimensional structures of proteins representative of the range of protein structure and function found in nature. This book examines the three dimensional structure of various proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy.
Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.

While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.

Introduction; Analysis of genomes for structural genomics and the limitations of sequence analysis; Structure determination pipeline for structural genomics;Gene cloning and protein expression;Gene cloning and expression of membrane proteins; High-throughput protein purification for x-ray crystallography and NMR; High-throughput protein crystallization; Structure determination using synchrotron radiation; Application of NMR to structural genomics; Development of key high-throughput technologies: High-throughput functional screening; Development of key high-throughput technologies: Structure prediction and homology modeling; Functional inferences from structure; Structural genomics programs (SARS case); Structural genomics programs (E.coli);Structural genomics as a structural foundation for drug discovery; Structural genomics of eukaryote; Structural genomics of complexes; Dissemination structural genomics data to biology community

Reihe/Serie Advances in Protein Chemistry and Structural Biology
Verlagsort San Diego
Sprache englisch
Maße 152 x 229 mm
Gewicht 340 g
Themenwelt Informatik Weitere Themen Bioinformatik
Naturwissenschaften Biologie Biochemie
Naturwissenschaften Biologie Genetik / Molekularbiologie
ISBN-10 0-12-374442-3 / 0123744423
ISBN-13 978-0-12-374442-5 / 9780123744425
Zustand Neuware
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