Gene Expression and Regulation

Jun Ma, PhD, is an Associate Professor, Division of Developmental Biology, Cincinnati Children's Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Section I: The History * 1. Transcription--Then and Now; * Section II: The Machinery * 2. GTFs, PIC Information; * 3. RNA Polymerase Holoenzyme; * 4. Mediators/Adaptors, TBP and TAFs; * 5. Chromation and Chromation Remodeling; * 6. HATs and HDACs; * 7. Core Promoter Elements; * Section III: The Regulators * 8. Activators and Activation Mechanisms; * 9. Repressors and Repression Mechanisms; * 10. STATs; * 11. Smads; * 12. RB-E2F; * 13. AP-1; * 14. HIV Tat; * 15. p53; * 16. Actions of Nuclear Receptors; * 17. NFAT; * 18. Homeodomain Proteins; * 19. NFkB/Rel; * 20. ATFs; * Section IV: The Genome * 21. Insulators and Chromatin Boundaries; * 22. Heterochromatin and X Inactivation; * 23. DNA Methylation and Imprinting; * 24. Genomics and Transcription; * 25. DNA Synthesis/Integrity and Transcription; * 26. Cell Death and Transcription; * Section V: Special Topics * 27. RNA Processing; * 28. DNA Topology and Transcription; * 29. miRNA and RNAi; * 30. Developmental Signals and Transcription; * 31. Gene Expression in Plants; * 32. Bacterial Gene Regulation; * 33. Gene Therapy; * 34. Transcription Factor Dynamics; * 35. Actin, Myosin, and ARPs in Transcription