Structured Biological Modelling

Michael Kraus, Bernhard Wolf

PrefaceHolistic Approaches for Data Acquisition in Cell Biology-The Basis for SBMHolistic Versus Molecular Biological Methods: A Fundamental Complementarity Between Experimental StrategiesSelected Minimal-Invasive Techniques for Holistic Data Acquisition in Cell BiologyAnalytical Light MicroscopyAnalytical Electron MicroscopyFurther Analytical Techniques with Relevance for SBMImage AnalysisCellular Biosensors: Powerful Electrical Devices for the Detection of Biomolecular SignalsStructured Biological Modelling (SBM)-Technique and ApplicationsThe SBM CyclePreliminary Remarks about the Modelling of Biological SystemsStructured AnalysisMathematical Specification of the DFD ModelStochastic Simulation of the Mathematical ModelSBM Applied to Intracellular Ca2+ OscillationsThe Experimental BasisCritical Discussion of Minimal Models for Intracellular Ca2+ OscillationsMicroscopic View of Ca2+ Oscillators Represented by Stochastic Models: The Stochastic Two-Pool OscillatorA SBM Model for Oscillatory Intracellular Ca2+ Waves in Nonexcitable CellsMinimal Model of the Cellular Signal Transduction NetworkThe Cell CycleModules of the Intracellular Signal NetworkStructured Analysis of Proliferation-Associated Cell SignalingThe Minimal Model of the Mitogenic Signal Transduction Network: Discussion and OutlookEmergence of Self-Organization in Tumor BiologyBrief Phenomenology of Self-Organized Cellular StructuresPhysical PreliminariesPhase Transitions in Cell Cycle and Neoplastic GrowthNeoplastic Growth as a Process of Cellular Self-Organization?The Hierarchy of Biological Systems: Microenvironmental Hydrogen Ion Concentration as Central Order Parameter for Invasive Tumor GrowthSummary and OutlookReferences