RNA Design -

RNA Design

Methods and Protocols
Buch | Hardcover
230 Seiten
2024
Springer-Verlag New York Inc.
978-1-0716-4078-4 (ISBN)
235,39 inkl. MwSt
Chapters details traditional RNA design in secondary structure, RNA design in tertiary structure, and RNA design applications and assessments.
This volume provides comprehensive methods on RNA design. Chapters details traditional RNA design in secondary structure,  RNA design in tertiary structure, and RNA design applications and assessments. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.



 



Authoritative and cutting-edge, RNA Design: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Sequence design for RNA-RNA interactions.- Sequence design using RNAStructure.- Riboswitch design using MODENA.- Complex in-silico RNA design with MoiRNAiFold.- Machine learning for RNA design – LEARNA.- Simulated Annealing for RNA design with SIMARD.- RNA design using incaRNAfbinv demonstrated with the identification of functional RNA motifs in hepatitis delta virus.- gRNAde: a geometric deep learning pipeline for 3D RNA inverse design.- Towards increasing the credibility of RNA design.- 3D-based RNA function prediction tools in rnaglib.- Generative modeling of RNA sequence families with restricted Boltzmann  machines.- SHAPE probing to screen computationally designed RNA.- A computational approach for designing synthetic riboswitches for next-generation RNA therapeutics.- Monte Carlo inverse RNA folding.- Generating artificial ribozymes using sparse coevolutionary models.- Datasets for benchmarking RNA design algorithms.- The evolution of nucleic acid-based diagnosis methods from (pre-)CRISPR to CRISPR era and the associated machine/deep leaning approaches in relevant RNA design.

Erscheint lt. Verlag 1.11.2024
Reihe/Serie Methods in Molecular Biology
Zusatzinfo 4 Illustrations, black and white; CCXXX, 230 p. 81 illus., 77 illus. in color.
Verlagsort New York, NY
Sprache englisch
Maße 178 x 254 mm
Themenwelt Mathematik / Informatik Informatik Theorie / Studium
Informatik Weitere Themen Bioinformatik
Naturwissenschaften Biologie
Schlagworte CRISPRon and CRISPRoff • Incarnation • Infrared/RNApond • NUPACK • Vienna RNA package
ISBN-10 1-0716-4078-X / 107164078X
ISBN-13 978-1-0716-4078-4 / 9781071640784
Zustand Neuware
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