Experimental Design and Reproducibility in Preclinical Animal Studies

lt;p> José M. Sánchez Morgado, DVM, MSc, PhD, Dip. ECLAM qualified as veterinarian at the Universidad Complutense of Madrid. He is European Veterinary Specialist in Laboratory Animal Medicine and Veterinary Council Ireland recognised Specialist in Laboratory Animal Medicine. Dr. Sánchez Morgado is currently Director of Comparative Medicine and Adjunct Associate Professor at Trinity College Dublin. He is also one of the Editors in Chief of the Laboratory Animals journal. Dr. Sánchez Morgado described a case of non-human primate intersex in 2003. Furthermore, he published studies on virulence of canine coronaviruses, Mycobacterium gordonae infection of amphibians, and on diagnostic discrepancies of Helicobacter spp., a common rodent pathogen, by different laboratories, and a new helicobacter diagnostic assay. He has worked as Designated Veterinarian in the UK, Spain and the Republic of Ireland, and has managed two laboratory animal care and user programs.

An introduction to reproducibility in the context of animal research.- Rodent Genetics.- Animal and environmental factors that influence reproducibility.- Microbiology and Microbiome.- Effects of untreated pain, anesthesia and analgesia in animal experimentation.- Why do we need a statistical experiment design.- Statistical tests and Sample size calculations.- Design of experiments.- Scholarly Publishing and Scientific Reproducibility.- Systematic reviews.- Planning animal experiments.