Genome Transcriptome and Proteome Analysis
John Wiley & Sons Inc (Verlag)
978-0-470-84954-5 (ISBN)
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A clear, concise introduction to the subject of modern genomic analysis
A technology-oriented approach including the latest developments in the field
Invaluable to those students taking courses in Bioinformatics, Human Genetics, Biochemistry and Molecular Biology
Alain Bernot is a graduate of the école normale supérieure, PHD, and Professor at the Université d'Evry. He is currently working in a genetic therapy programme at Genethon. He previously directed the sequencing and analysis of a vertebrate genome (Tetraodon nigroviridis), and contributed to the identification of a gene responsible for a human genetic disease (Mediterranean familial fever).
Introduction. 1 General introduction.
1.1 Revision of molecular genetics.
1.2 The tools of molecular biology.
1.3 Specifics of the genome programmes.
1.4 The species analysed.
2 Linkage maps.
2.1. Tools and methods in genetic mapping.
2.2 The development of genetic maps.
2.3 Radiation hybrid maps.
2.4 Conclusion.
3 Physical maps.
3.1 Local maps or small genomes.
3.2 Strategies for physical mapping of the human genome.
3.3 Maps of the human genome.
3.4 Conclusion.
4 Genome sequencing .
4.1 Strategic choices.
4.2 Prokaryotic genomes.
4.3 Genomes of model eukaryotes.
4.4 The human genome. & lt;div>
4.5 Conclusion.
5 Sequencing cDNA and the transcriptome.
5.1 Strategies of cDNA sequencing.
5.2 The economic stakes.
5.3 The analysis of cDNA sequences.
5.4 The transcriptome.
5.5 Conclusion.
6 The proteome.
6.1 Basic techniques.
6.2 Transgenesis .
6.3 Mutagenesis.
6.4 Two-dimensional electrophoresis and identification of proteins.
6.5 Identification of protein interactions by twin hybrids.
6.6 Chip technology.
6.7 Analysis of three-dimensional structure.
6.8 Conclusions.
7 Identification of genes responsible for disease.
7.1 Genetic diseases.
7.2 Functional cloning and chromosomal anomalies.
7.3 Strategy for positional cloning.
7.4 What is the future for the cloning of disease-causing genes?
7.5 Conclusion.
General conclusion.
Bibliography.
Erscheint lt. Verlag | 17.9.2004 |
---|---|
Verlagsort | New York |
Sprache | englisch |
Maße | 152 x 228 mm |
Gewicht | 539 g |
Themenwelt | Informatik ► Weitere Themen ► Bioinformatik |
Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
ISBN-10 | 0-470-84954-1 / 0470849541 |
ISBN-13 | 978-0-470-84954-5 / 9780470849545 |
Zustand | Neuware |
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