Translational Bioinformatics for Therapeutic Development -

Translational Bioinformatics for Therapeutic Development

Joseph Markowitz (Herausgeber)

Buch | Softcover
317 Seiten
2021 | 1st ed. 2021
Springer-Verlag New York Inc.
978-1-0716-0851-7 (ISBN)
139,09 inkl. MwSt
This volume introduces Translational Bioinformatics as it relates to therapeutic development, and addresses the techniques needed to effectively translate large data sets to relevant biological networks. Chapters detail clinical informatics infrastructure, and leverage pathology, immunology, pharmacology, genomic, proteomic, and metabolomic informatics approaches.   Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls.



 



Authoritative and practical, Translational Bioinformatics for Therapeutic Development: Methods and Protocols aims to ensure success in the study of Translational Bioinformatics.

Development and Optimization of Clinical Informatics Infrastructure to Support Bioinformatics at an Oncology Center.- Leveraging Pathology Informatics Concepts to Achieve Discrete Lab Data for Clinical Use and Translational Research.- Cohort Identification for Translational Bioinformatics Studies.- Transitioning Clinical Practice Guidelines into the Electronic Health Record through Clinical Pathways.- Variable Selection for Time-to-Event Data.- Binary Classification for Failure Risk Assessment.- Challenges and Opportunities of Genomic Approaches in Therapeutics Development.- Accessible Pipeline for Translational Research using TCGA: Examples of Relating Gene Mechanism to Disease Specific Outcomes.- Statistical and Bioinformatics Analysis of Data from Bulk and Single-Cell RNA Sequencing Experiments.- Investigating Inter- and Intra-Sample Diversity of  Single-Cell RNA Sequencing Datasets.- Managing a Large-scale Multi-Omics Project: A Team Science Case Study in Proteogenomics.- Synergistic Drug Combination Prediction by Integrating Multi-omics Data in Deep Learning Models.- Introduction to Multi-Parametric Flow Cytometry and Analysis of High-Dimensional Data.- High Dimensional Flow Cytometry Analysis of Regulatory Receptors on Human T cells, NK cells, and NKT Cells*.- Quantitative Analysis of Bile Acid with UHPLC-MS/MS.- Sample Preparation and Data Analysis for NMR–based Metabolomics.








 

Erscheinungsdatum
Reihe/Serie Methods in Molecular Biology ; 2194
Zusatzinfo 66 Illustrations, color; 9 Illustrations, black and white; XV, 317 p. 75 illus., 66 illus. in color.
Verlagsort New York, NY
Sprache englisch
Maße 178 x 254 mm
Themenwelt Mathematik / Informatik Informatik Theorie / Studium
Informatik Weitere Themen Bioinformatik
Naturwissenschaften Biologie Genetik / Molekularbiologie
Schlagworte Biological Networks • Data Analysis • Informatics techniques • therapeutics • Translational Science
ISBN-10 1-0716-0851-7 / 1071608517
ISBN-13 978-1-0716-0851-7 / 9781071608517
Zustand Neuware
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