Computational Stem Cell Biology -

Computational Stem Cell Biology

Methods and Protocols

Patrick Cahan (Herausgeber)

Buch | Softcover
456 Seiten
2020 | 1st ed. 2019
Humana Press Inc. (Verlag)
978-1-4939-9226-3 (ISBN)
139,09 inkl. MwSt
This volume details methods and protocols to further the study of stem cells within the computational stem cell biology (CSCB) field. Chapters are divided into four sections covering the theory and practice of modeling of stem cell behavior, analyzing single cell genome-scale measurements, reconstructing gene regulatory networks, and metabolomics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Computational Stem Cell Biology: Methods and Protocols will be an invaluable guide to researchers as they explore stem cells from the perspective of computational biology.

Agent-Based Modeling to Delineate Spatiotemporal Control Mechanisms of the Stem Cell Niche.- Modeling Cellular Differentiation and Reprogramming with Gene Regulatory Networks.- Cell Population Model to Track Stochastic Cellular Decision-Making during Differentiation.- Automated Formal Reasoning to Uncover Molecular Programs of Self-Renewal.- Mathematical Modeling of Clonal Stem Cell Dynamics.- Computational Tools for Quantifying Concordance in Single Cell Fate.- Quantitative Modeling of the Waddington Epigenetic Landscape.- Modeling Gene Networks to Understand Multistability in Stem Cells.- Trajectory Algorithms to Infer Stem Cell Fate Decisions.- Gene Regulatory Networks from Single Cell Data for Exploring Cell Fate Decisions.- Reconstructing Gene Regulatory Networks that Control Hematopoietic Commitment.- Investigating Cell Fate Decisions with ICGS Analysis of Single Cells.- Lineage Inference and Stem Cell Identity Prediction using Single Cell RNA-Sequencing Data.- Dynamic Network Modeling of Stem Cell Metabolism.- Metabolomics in Stem Cell Biology Research.- Molecular Interaction Networks to Select Factors for Cell Conversion.- A Computational Approach for Cell Fate Reprogramming.- Computational Analysis of Aneuploidy in Pluripotent Stem Cells.- Cell Fate Engineering Tools for iPSC Disease Modeling.

Erscheinungsdatum
Reihe/Serie Methods in Molecular Biology ; 1975
Zusatzinfo 95 Illustrations, color; 12 Illustrations, black and white; XI, 456 p. 107 illus., 95 illus. in color.
Verlagsort Totowa, NJ
Sprache englisch
Maße 178 x 254 mm
Themenwelt Mathematik / Informatik Informatik Theorie / Studium
Informatik Weitere Themen Bioinformatik
Naturwissenschaften Biologie Genetik / Molekularbiologie
Naturwissenschaften Biologie Zellbiologie
Schlagworte engineered cells • fetal tissues • gene regulatory networks • single-cell transcriptome data • teratomas
ISBN-10 1-4939-9226-0 / 1493992260
ISBN-13 978-1-4939-9226-3 / 9781493992263
Zustand Neuware
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