Design and Analysis of DNA Microarray Investigations - Richard M. Simon, Edward L. Korn, Lisa M. McShane, Michael D. Radmacher, George W. Wright

Design and Analysis of DNA Microarray Investigations

Buch | Hardcover
200 Seiten
2004
Springer-Verlag New York Inc.
978-0-387-00135-7 (ISBN)
160,49 inkl. MwSt
Discusses the analysis of gene expression profile data from DNA micorarray studies. This title provides a review of available methods and presents it in a manner that is intelligible to biologists. It offers an understanding of the design and analysis of experiments utilizing microarrays to benefit scientists.
DNA microarrays are an important technology for studying gene expression. With a single hybridization, the level of expression of thousands of genes, or even an entire genome, can be estimated for a sample of cells. Consequently, manylaboratoriesareattemptingtoutilizeDNAmicroarraysintheirresearch. Whereaslaboratoriesarewellpreparedtoaddressthesigni?cantexperimental challenges in obtaining reproducible data from this RNA-based assay, inv- tigators are less prepared to analyze the large volumes of data produced by DNA microarrays. Although many software packages have been developed for the analysis of DNA microarray data, software alone is insu?cient. One needs knowledge aboutthevariousaspectsofdataanalysisinordertoselectandutilizesoftware e?ectively. There is a plethora of analysis methods being published and it is di?cult for biologists to determine which methods are valid and appropriate for their problems. Many scientists have learned that software is not an adequate substitute for biostatistical knowledge and seek statistical collaborators. Unfortunately, there is presently a shortage of statisticians who are available and knowled- able about DNA microarrays. For statisticians to be e?ective collaborators in anyarea,theymustinvestthetimetounderstandthesubjectmatterareaand become familiar with the literature so that they can ask the right questions and identify the key issues. Our objectives in this book are twofold: to provide scientists with infor- tion about the design and analysis of studies using DNA microarrays that will enable them to plan and analyze their own studies or to work with statistical collaborators e?ectively, and to aid statistical and computational scientists wishing to develop expertise in this area.

DNA Microarray Technology.- Design of DNA Microarray Experiments.- Image Analysis.- Quality Control.- Array Normalization.- Class Comparison.- Class Prediction.- Class Discovery.

Erscheint lt. Verlag 8.1.2004
Reihe/Serie Statistics for Biology and Health
Zusatzinfo 19 Illustrations, color; 39 Illustrations, black and white; X, 200 p. 58 illus., 19 illus. in color.
Verlagsort New York, NY
Sprache englisch
Maße 155 x 235 mm
Themenwelt Mathematik / Informatik Mathematik
Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Studium
Naturwissenschaften Biologie Genetik / Molekularbiologie
ISBN-10 0-387-00135-2 / 0387001352
ISBN-13 978-0-387-00135-7 / 9780387001357
Zustand Neuware
Haben Sie eine Frage zum Produkt?
Mehr entdecken
aus dem Bereich

von Hannes Leischner

Buch | Softcover (2023)
Urban & Fischer in Elsevier (Verlag)
27,00
Resilienz innovativ stärken : ein Praxishandbuch

von Christa Diegelmann; Margarete Isermann; Tanja Zimmermann

Buch | Softcover (2023)
Kohlhammer (Verlag)
36,00