In the Beginning Was the Worm

The human genome project was possible due to the 30-year struggle to decode the complete DNA of a nematode worm. This title tells of the remarkable characters whose struggle changed our approach to modern science, including: Sydney Bremmer, John Sulston, Bob Orvitz and Fred Sanger.

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The fascinating story of the quest to decode for the first time the entire DNA of a living creature -- a tiny transparent worm only half a millimetre long. This book is an account of the first great triumph of genomics: the thirty-year struggle to decode the complete DNA of a nematode worm. Success in this was what made the human genome project possible. IN THE BEGINNING WAS THE WORM is an exciting but scrupulous account of a genuine scientific triumph, which will delight both those who know the subject and those who don't. IN THE BEGINNING WAS THE WORM tells of some remarkable characters who have changed our approach to science irrevocably, among them Sydney Brenner, a heroic dreamer who first thought of understanding an animal as a sort of biological Meccano; John Sulston, his first post-doctoral student, who managed to raise [pound]30 million; his friend, Bob Orvitz, who has, to all intents and purposes, spent more than thirty years studying the 22 cells of a worm's vulva; and Fred Sanger, the only man to have won two Nobel Prizes in the same discipline.
Decades of painstaking research triumphed in 1998, when this worm was the first creature to have all its DNA mapped -- but now what? We still don't know how to build a single worm. In this intriguing story of dreams and disillusionment, Andrew Brown contemplates the next fifty years of biological science, and the way that ignorance expands to surround all available knowledge.