Nutritional Epigenomics

Bradley S. Ferguson is an Associate Professor of Nutrition at the University of Nevada, Reno, Nevada. His lab adopts integrative, translational research approaches that encompass bioinformatics, in vitro cell culture, and in vivo animal models to elucidate dietary food components that act as epigenetic modifiers, as well as the role of dietary epigenetic modifiers on pathological cardiac signaling, gene expression, and remodeling. He also seeks to understand how sarcomere protein acetylation links metabolic disease (obesity and diabetes) to pathological cardiac remodeling and skeletal muscle dysfunction. Dr. Ferguson has published his findings across a wide range of peer-reviewed journals, including Scientific Reports, Journal of Animal Science, American Journal of Physiology, Cell Reports, PNAS, and the Journal of Molecular and Cellular Cardiology.

SECTION I Introduction 1. Introduction to nutritional epigenomics

SECTION II Epigenetic regulators 2. DNA methylation and chromatin modifications 3. Small non-coding RNAs as epigenetic regulators

SECTION III Epigenomic regulation of disease 4. The impact of race and ethnicity in the social epigenomic regulation of disease 5. The epigenomic impact of methylation in metabolic dysfunction and cancer 6. The role for DNA/RNA methylation on neurocognitive dysfunctions 7. Histone acylation in the epigenomic regulation of insulin action and metabolic disease 8. Cancer and non-coding RNAs 9. Race in the social-epigenomic regulation of pre- and perinatal development 10. Maternal nutrition, epigenetic programming and metabolic syndrome 11. Epigenetic inheritance of metabolic signals 12. The paternal diet regulates the offspring epigenome and health

SECTION V Nutritional epigenomics and the circadian clock 13. The interplay between diet, epigenetics and the circadian clock 14. Epigenetic regulation of the fetal circadian clock: implications for nutritional programming of circadian and metabolic function 15. The role for the microbiome in the regulation of the circadian clock and metabolism

SECTION VI Carloric restriction and exercise in the epigenomic regulation of aging and disease 16. Epigenomic reprogramming of caloric restriction on aging 17. Dietary restriction in the epigenomic regulation of cardiovascular diseases 18. Epigenomic adaptations of exercise in the control of metabolic disease and cancer

SECTION VII Macro- and micronutrients as epigenomic regulators of health and disease 19. B-vitamins and one-carbon metabolism: impacts on the epigenome during development 20. Food bioactives in the epigenomic regulation of metabolic disease 21. Stilbenoids as dietary regulators of the cancer epigenome 22. Regulation of non-coding RNAs by phytochemicals for cancer therapy 23. Short chain fatty acids as epigenetic and metabolic regulators of neurocognitive health and disease

SECTION VIII Diet, epigenetics and the microbiome 24. Diet-microbiome interactions and the regulation of the epigenome 25. Gut dysbiosis and its epigenomic impact on disease 26. Microbiota, the brain and epigenetics