Advances in Nucleic Acid Therapeutics

History and Development of Nucleotide Analogues in Nucleic Acids Drugs;

Mechanisms of Antisense Oligonucleotides;

The Medicinal Chemistry of RNase H-activating Antisense Oligonucleotides;

Antisense Technology: Liver Targeting and Beyond for Drug Discovery;

Oligonucleotide-based Toll-like Receptor Antagonists and Therapeutic Applications;

Splicing Modulation for Therapeutics;

Targeting Toxic Repeats;

Research and Development of Oligonucleotides Targeting MicroRNAs (miRNAs);

Oligonucleotide Targeting of Long Non-coding RNAs;

Conjugate-mediated Delivery of RNAi-based Therapeutics: Enhancing Pharmacokinetics-Pharmacodynamics Relationships of Medicinal Oligonucleotides;

Liver-targeted RNAi Therapeutics: Principles and Applications;

Advances and Challenges of RNAi-Based Anti-HIV Therapeutics;

Nucleic Acid Innate Immune Receptors;

Synthetic Agonists of Toll-like Receptors and Therapeutic Applications;

Prostate-specific Membrane Antigen (PSMA) Aptamers for Prostate Cancer Imaging and Therapy;

Aptamers and Clinical Applications;

CRISPR-based Technologies for Genome Engineering: Properties, Current Improvements and Applications in Medicine;

Therapeutic Potential of Ribozymes;

Large-scale Automated Synthesis of Therapeutic Oligonucleotides: A Status Update;

Preclinical and Clinical Drug-metabolism, Pharmacokinetics and Safety of Therapeutic Oligonucleotides;

Subject Index