New Perspectives in Drug Design

Some interactions of macromolecules with low molecular weight ligands - recent advances in peptidomimetic research, R.F. Hirschmann; drug design based on structural similarity and molecular biology, B.P. Roques; topochemistry and inhibition of carbohydrate-mediated cell adhesion, C.H. Wong; the interplay between intuition and computer assistance in the design of enzyme inhibitors - macrocyclic phosphonamidates as inhibitors of thermolysin, P.A. Bartlett et al; total synthesis of taxol and designed taxoids, K.C. Nicolaou and R.K. Guy; the age of structure - the role of protein crystallography in drug design, D. Ringe and G.A. Petsko; molecular modelling of the adenosine A receptor, A.P.I. Jzerman et al; challenges in structure-based drug design, I.D. Kuntz et al; optimization of combinatoric problems in structure generation for drug design, P.M. Dean et al; free energy calculations in drug design, a practical guide, A. Mark and W.F. van Gunsteren; conformational analysis in site-directed molecular design, A.R. Leach; application of computer-aided drug design techniques to lead generation, R.A. Lewiset al; "molecular mimics" as approaches for rational drug design, A. Laoui et al; modelling and chemometrics in medicinal chemistry, S. Clementi et al.