The Design and Analysis of Clinical Experiments

This reference book on clinical experimentation focuses on principles that are especially useful in the design and analysis of studies on human subjects. It shows how to choose between modern and classical competing designs for a clinical study - such as crossover designs, multicenter studies, and repeated measure experiments - how to carry out each design and analyze the resulting data. The book provides many practical examples, end-of-chapter problems and references, and solutions to each problem. The mathematical bases are given for several design strategies as well as for their analysis. Also provided are tables of critical values, 200 random permutations of the first one hundred integers, and an appendix on programmable methods for determining sample sizes.